Evidence for neurogenesis in the adult mammalian substantia nigra

被引:436
作者
Zhao, M
Momma, S
Delfani, K
Carlén, M
Cassidy, RM
Johansson, CB
Brismar, H
Shupliakov, O
Frisén, J
Janson, AM
机构
[1] Med Nobel Inst, Dept Neurosci, SE-17177 Stockholm, Sweden
[2] Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden
[3] Karolinska Inst, Dept Woman & Child Hlth, SE-17177 Stockholm, Sweden
关键词
D O I
10.1073/pnas.1131955100
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of neurogenesis is increased after a lesion. The number of new neurons generated under physiological conditions in substantial nigra pars compacta was found to be several orders of magnitude smaller than in the granular cell layer of the dentate gyrus of the hippocampus. However, if the rate of neuronal turnover is constant, the entire population of dopaminergic neurons in substantia nigra could be replaced during the lifespan of a mouse. These data indicate that neurogenesis in the adult brain is more widespread than previously thought and may have implications for our understanding of the pathogenesis and treatment of neurodegenerative disorders such as Parkinson's disease.
引用
收藏
页码:7925 / 7930
页数:6
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