Ginkgo biloba neuroprotection: Therapeutic implications in Alzheimer's disease

被引：54

作者：

Luo, Yuan ^{[1
]}

机构：

[1] Univ Southern Mississippi, Dept Biol Sci, Box 5018, Hattiesburg, MS 39406 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2001年 / 3卷 / 04期

关键词：

D O I：

10.3233/JAD-2001-3407

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An extract of Ginkgo biloba leaves, EGb761, is becoming one of the most popular dietary supplements in the United States to enhance memory. In Europe it is a commonly prescribed drug for treatment of age-related deterioration, including degenerative dementias of the Alzheimer type (AD). Substantial experimental evidence indicates that EGb761 has neuroprotective potency under conditions such as ischemia, seizures and peripheral nerve damage. However, the mechanisms of such neuroprotective effects remain unknown, partially because of the complex chemical composition of EGb761 and the resulting so-called "polyvalent" action. This review focuses on cellular and molecular approaches towards understanding the polyvalent action of EGb761 neuroprotective effect. Two potential mechanisms of action, reducing oxidative damage and stimulating cell survival machinery, are discussed. Better understanding of the neuroprotective mechanisms of EGb761 will provide impetus for possible combination therapies and for the design of rational, "mechanism-based" strategies that target age-related neurodegeneration and Alzheimer's disease.

引用

页码：401 / 407

页数：7

共 72 条

[1] Inhibition of serum deprivation- and staurosporine-induced neuronal apoptosis by Ginkgo biloba extract and some of its constituents [J].

Ahlemeyer, B ;

Möwes, A ;

Krieglstein, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 367 (2-3) :423-430

[2]

[Anonymous], 1998, GINKGO BILOBA EXTRAC

[3] GINKGO-BILOBA EXTRACT FACILITATES RECOVERY FROM PENETRATING BRAIN INJURY IN ADULT MALE-RATS [J].

ATTELLA, MJ ;

HOFFMAN, SW ;

STASIO, MJ ;

STEIN, DG .

EXPERIMENTAL NEUROLOGY, 1989, 105 (01) :62-71

[4] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].

BARTUS, RT ;

DEAN, RL ;

BEER, B ;

LIPPA, AS .

SCIENCE, 1982, 217 (4558) :408-417

[5] The ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β-amyloid [J].

Bastianetto, S ;

Ramassamy, C ;

Doré, S ;

Christen, Y ;

Poirier, J ;

Quirion, R .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (06) :1882-1890

[6] Platelet activating factor receptor expression is associated with neuronal apoptosis in an in vivo model of excitotoxicity [J].

Bennett, SAL ;

Chen, JH ;

Pappas, BA ;

Roberts, DCS ;

Tenniswood, M .

CELL DEATH AND DIFFERENTIATION, 1998, 5 (10) :867-875

[7] PLATELET-ACTIVATING FACTOR ANTAGONIST BN52021 DECREASES ACCUMULATION OF FREE POLY-UNSATURATED FATTY-ACID IN MOUSE-BRAIN DURING ISCHEMIA AND ELECTROCONVULSIVE SHOCK [J].

BIRKLE, DL ;

KURIAN, P ;

BRAQUET, P ;

BAZAN, NG .

JOURNAL OF NEUROCHEMISTRY, 1988, 51 (06) :1900-1905

[8]

BRAQUET P, 1987, PHARMACOL REV, V39, P97

[9]

Butterfield DA, 1999, REV NEUROSCIENCE, V10, P141

[10] The third intracellular domain of the platelet-activating factor receptor is a critical determinant in receptor coupling to phosphoinositide phospholipase C activating G proteins - Studies using intracellular domain minigenes and receptor chimeras [J].

Carlson, SA ;

Chatterjee, TK ;

Fisher, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (38) :23146-23153

← 1 2 3 4 5 6 7 8 →