What is mild cognitive impairment? Variations in definitions and evolution of nondemented persons with cognitive impairment

被引:112
作者
Palmer, K
Fratiglioni, L
Winblad, B
机构
[1] Stockholm Gerontol Res Ctr, S-11382 Stockholm, Sweden
[2] Karolinska Inst, Div Geriatr Epidemiol, Aging Res Ctr, Stockholm, Sweden
来源
ACTA NEUROLOGICA SCANDINAVICA | 2003年 / 107卷
关键词
mild cognitive impairment; evolution; Alzheimer's disease; dementia; mortality; diagnostic criteria;
D O I
10.1034/j.1600-0404.107.s179.2.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Numerous studies have endeavoured to explore the nature of cognitive impairment in nondemented elderly persons. Comparison of this literature is hampered by huge variations in criteria and methodology. Despite these limitations, there are repeated reports that nondemented persons with cognitive impairment have a higher chance of progressing to dementia. Evidence also indicates higher mortality in cognitively impaired persons but there is also a chance of improvement in cognition over time. The current paper provides an overview of the various concepts and criteria proposed for cognitive impairment in nondemented persons, discusses some of the problems with current research in this field, and presents some of the findings concerning the evolution of cognitive impairment in relation to dementia, mortality and cognitive improvement.
引用
收藏
页码:14 / 20
页数:7
相关论文
共 34 条
[1]   Cognitive impairment and mortality among nonagenarians: The Danish 1905 cohort survey [J].
Andersen, K ;
Nybo, H ;
Gaist, D ;
Petersen, HC ;
McGue, M ;
Jeune, B ;
Vaupel, JW ;
Christensen, K .
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2002, 13 (03) :156-163
[2]   Progression to dementia in patients with isolated memory loss [J].
Bowen, J ;
Teri, L ;
Kukull, W ;
McCormick, W ;
McCurry, SM ;
Larson, EB .
LANCET, 1997, 349 (9054) :763-765
[3]   Mild cognitive impairments predict dementia in nondemented elderly patients with memory loss [J].
Bozoki, A ;
Giordani, B ;
Heidebrink, JL ;
Berent, S ;
Foster, NL .
ARCHIVES OF NEUROLOGY, 2001, 58 (03) :411-416
[4]   A LOW, NORMAL SCORE ON THE MINI-MENTAL-STATE-EXAMINATION PREDICTS DEVELOPMENT OF DEMENTIA AFTER 3 YEARS [J].
BRAEKHUS, A ;
LAAKE, K ;
ENGEDAL, K .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1995, 43 (06) :656-661
[5]   Age-Associated Memory Impairment: Proposed Diagnostic Criteria and Measures of Clinical Change - Report of a National Institute of Mental Health Work Group [J].
Crook, Thomas ;
Bartus, Raymond T. ;
Ferris, Steven H. ;
Whitehouse, Peter ;
Cohen, Gene D. ;
Gershon, Samuel .
DEVELOPMENTAL NEUROPSYCHOLOGY, 1986, 2 (04) :261-276
[6]  
Cullum S, 2000, INT J GERIATR PSYCH, V15, P853, DOI 10.1002/1099-1166(200009)15:9<853::AID-GPS211>3.3.CO
[7]  
2-K
[8]   Predicting conversion to Alzheimer disease using standardized clinical information [J].
Daly, E ;
Zaitchik, D ;
Copeland, M ;
Schmahmann, J ;
Gunther, J ;
Albert, M .
ARCHIVES OF NEUROLOGY, 2000, 57 (05) :675-680
[9]   Questionable dementia: Clinical course and predictors of outcome [J].
Devanand, DP ;
Folz, M ;
Gorlyn, M ;
Moeller, JR ;
Stern, Y .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1997, 45 (03) :321-328
[10]   COGNITIVE IMPAIRMENT IN THE NONDEMENTED ELDERLY - RESULTS FROM THE CANADIAN STUDY OF HEALTH AND AGING [J].
EBLY, EM ;
HOGAN, DB ;
PARHAD, IM .
ARCHIVES OF NEUROLOGY, 1995, 52 (06) :612-619