Effect of increased blood glucose availability on glucose kinetics during exercise

被引:28
作者
Howlett, K
Angus, D
Proietto, J
Hargreaves, M
机构
[1] Univ Melbourne, Royal Melbourne Hosp, Dept Physiol, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Parkville, Vic 3052, Australia
关键词
liver glucose output; muscle glucose uptake; hyperglycemia;
D O I
10.1152/jappl.1998.84.4.1413
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
This study examined the effect of increased blood glucose availability on glucose kinetics during exercise. Five trained men cycled for 40 min at 77 +/- 1% peak oxygen uptake on two occasions. During the second trial (Glu), glucose was infused at a rate equal to the average hepatic glucose production (HGP) measured during exercise in the control trial (Con). Glucose kinetics were measured by a primed continuous infusion of D-[3-H-3]glucose. Plasma glucose increased during exercise in both trials and was significantly higher in Glu. HGP was similar at rest (Con, 11.4 +/- 1.2; Glu, 10.6 +/- 0.6 mu mol.kg(-1).min(-1)). After 40 min of exercise, HGP reached a peak of 40.2 +/- 5.5 mu mol.kg(-1).min(-1) in Con; however, in Glu, there was complete inhibition of the increase in HGP during exercise that never rose above the preexercise level. The rate of glucose disappearance was greater (P < 0.05) during the last 15 min of exercise in Glu. These results indicate that an increase in glucose availability inhibits the rise in HGP during exercise, suggesting that metabolic feedback signals can override feed-forward activation of HGP during strenuous exercise.
引用
收藏
页码:1413 / 1417
页数:5
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