Mouse Models of Diabetic Nephropathy

被引：342

作者：

Brosius, Frank C., III ^{[1
]}

Alpers, Charles E. ^{[2
]}

Bottinger, Erwin P. ^{[3
]}

Breyer, Matthew D. ^{[4
]}

Coffman, Thomas M. ^{[5
,6
]}

Gurley, Susan B. ^{[5
,6
]}

Harris, Raymond C. ^{[7
]}

Kakoki, Masao ^{[8
]}

Kretzler, Matthias ^{[1
]}

Leiter, Edward H. ^{[9
]}

Levi, Moshe ^{[10
,11
,12
]}

McIndoe, Richard A. ^{[13
]}

Sharma, Kumar ^{[14
]}

Smithies, Oliver ^{[8
]}

Susztak, Katalin ^{[15
]}

Takahashi, Nobuyuki ^{[8
]}

Takahashi, Takamune ^{[7
]}

机构：

[1] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[3] Mt Sinai Sch Med, Charles R Bronfman Inst Personalized Med, New York, NY USA

[4] Lilly Res Labs, Indianapolis, IN USA

[5] Duke Univ, Durham, NC USA

[6] VA Med Ctr, Durham, NC USA

[7] Vanderbilt Univ, Dept Med, Nashville, TN USA

[8] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA

[9] Jackson Lab, Bar Harbor, ME 04609 USA

[10] Univ Colorado, Dept Med, Denver, CO USA

[11] Univ Colorado, Dept Physiol, Denver, CO 80202 USA

[12] Univ Colorado, Dept Biophys, Denver, CO 80202 USA

[13] Med Coll Georgia, Ctr Biotechnol & Genom Med, Augusta, GA 30912 USA

[14] Univ Calif San Diego, Ctr Renal Translat Med, VA San Diego Hlth Syst, La Jolla, CA 92093 USA

[15] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2009年 / 20卷 / 12期

基金：

美国国家卫生研究院;

关键词：

NITRIC-OXIDE SYNTHASE; PERFORMANCE LIQUID-CHROMATOGRAPHY; GLOMERULAR-FILTRATION-RATE; CONVERTING-ENZYME GENE; GROWTH-FACTOR-BETA; MICROVASCULAR COMPLICATIONS; CREATININE DETERMINATION; RENAL COMPLICATIONS; PODOCYTE DEPLETION; HIGH GLUCOSE;

D O I：

10.1681/ASN.2009070721

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of reliable animal models that mimic human disease has delayed the identification of specific factors that cause or predict diabetic nephropathy. The Animal Models of Diabetic Complications Consortium (AMDCC) was created in 2001 by the National Institutes of Health to develop and characterize models of diabetic nephropathy and other complications. This interim report and our online supplement detail the progress made toward that goal, specifically in the development and testing of murine models. Updates are provided on validation criteria for early and advanced diabetic nephropathy, phenotyping methods, the effect of background strain on nephropathy, current best models of diabetic nephropathy, negative models, and views of future directions. AMDCC investigators and other investigators in the field have yet to validate a complete murine model of human diabetic kidney disease. Nonetheless, the critical analysis of existing murine models substantially enhances our understanding of this disease process.

引用

页码：2503 / 2512

页数：10

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