Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus

被引：56

作者：

Entenza, JM

Foster, TJ

Eidhin, DN

Vaudaux, P

Francioli, P

Moreillon, P ^{[1
]}

机构：

[1] CHU Vaudois, Dept Internal Med, Div Infect Dis, CH-1011 Lausanne, Switzerland

[2] Hop Univ Geneve, Div Infect Dis, CH-1211 Geneva, Switzerland

[3] Univ Dublin Trinity Coll, Moyne Inst Prevent Med, Dept Microbiol, Dublin 2, Ireland

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.68.9.5443-5446.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P > 0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P < 0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.

引用

页码：5443 / 5446

页数：4

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