Enantioselective synthesis of the tetracyclic left-hand substructure of solanoeclepin A

被引：27

作者：

Benningshof, JCJ

Blaauw, RH

van Ginkel, AE

Rutjes, FPJT

Fraanje, J

Goubitz, K

Schenk, H

Hiemstra, H

机构：

[1] Univ Amsterdam, Organ Chem Lab, Inst Mol Chem, NL-1018 WS Amsterdam, Netherlands

[2] Univ Amsterdam, Crystallog Lab, Inst Mol Chem, NL-1018 WS Amsterdam, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 16期

关键词：

D O I：

10.1039/b003757p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of the enantiopure left-hand substructure of solanoeclepin A is described. Key steps include a chromium-mediated coupling of an oxabicyclic aldehyde with a beta-ketoester-derived enol triflate to give a lactone, and a ring-closing metathesis reaction to form the seven-membered ring.

引用

收藏

页码：1465 / 1466

页数：2

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