Macrophages, Inflammation, and Insulin Resistance

被引：2102

作者：

Olefsky, Jerrold M. ^{[1
]}

Glass, Christopher K. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 2010年 / 72卷

关键词：

obesity; adipose tissue; skeletal muscle; Kupffer cell; ACTIVATED RECEPTOR-GAMMA; ADIPOSE-TISSUE INFLAMMATION; GLYCATION END-PRODUCTS; TUMOR-NECROSIS-FACTOR; TOLL-LIKE RECEPTORS; ENDOPLASMIC-RETICULUM STRESS; DEPENDENT DIABETES-MELLITUS; PPAR-GAMMA; FATTY-ACIDS; NUCLEAR RECEPTORS;

D O I：

10.1146/annurev-physiol-021909-135846

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Obesity induces an insulin-resistant state in adipose tissue, liver, and muscle and is a strong risk factor for the development of type 2 diabetes mellitus. Insulin resistance in the setting of obesity results from a combination of altered functions of insulin target cells and the accumulation of macrophages that secrete proinflammatory mediators. At the molecular level, insulin resistance is promoted by a transition in macrophage polarization from an alternative M2 activation state maintained by STAT6 and PPA.Rs to a classical M1 activation state driven by NE-kappa B, AP1, and other signal-dependent transcription factors that play crucial roles in innate immunity. Strategies focused on inhibiting the inflammation/insulin resistance axis that otherwise preserve essential innate immune functions may hold promise for therapeutic intervention.

引用

页码：219 / 246

页数：28

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