Similar network activity from disparate circuit parameters

被引:685
作者
Prinz, AA
Bucher, D
Marder, E
机构
[1] Brandeis Univ, Volen Ctr, Waltham, MA 02454 USA
[2] Brandeis Univ, Dept Biol, Waltham, MA 02454 USA
关键词
D O I
10.1038/nn1352
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
It is often assumed that cellular and synaptic properties need to be regulated to specific values to allow a neuronal network to function properly. To determine how tightly neuronal properties and synaptic strengths need to be tuned to produce a given network output, we simulated more than 20 million versions of a three-cell model of the pyloric network of the crustacean stomatogastric ganglion using different combinations of synapse strengths and neuron properties. We found that virtually indistinguishable network activity can arise from widely disparate sets of underlying mechanisms, suggesting that there could be considerable animal-to-animal variability in many of the parameters that control network activity, and that many different combinations of synaptic strengths and intrinsic membrane properties can be consistent with appropriate network performance.
引用
收藏
页码:1345 / 1352
页数:8
相关论文
共 50 条
[1]   ANALYSIS OF NEURON MODELS WITH DYNAMICALLY REGULATED CONDUCTANCES [J].
ABBOTT, LF ;
LEMASSON, G .
NEURAL COMPUTATION, 1993, 5 (06) :823-842
[2]  
[Anonymous], 1998, METHODS NEURONAL MOD
[3]   Altered electrical properties in Drosophila neurons developing without synaptic transmission [J].
Baines, RA ;
Uhler, JP ;
Thompson, A ;
Sweeney, ST ;
Bate, M .
JOURNAL OF NEUROSCIENCE, 2001, 21 (05) :1523-1531
[4]  
BELL AJ, 1992, ADV NEURAL INFORMATI, P59
[5]   Robustness of the bistable behavior of a biological signaling feedback loop [J].
Bhalla, US ;
Iyengar, R .
CHAOS, 2001, 11 (01) :221-226
[6]   How robust are switches in intracellular signaling cascades? [J].
Blüthgen, N ;
Herzel, H .
JOURNAL OF THEORETICAL BIOLOGY, 2003, 225 (03) :293-300
[7]   Functional uncoupling of linked neurotransmitter effects by combinatorial convergence [J].
Brezina, V ;
Orekhova, IV ;
Weiss, KR .
SCIENCE, 1996, 273 (5276) :806-810
[8]   Maintaining the stability of neural function: A homeostatic hypothesis [J].
Davis, GW ;
Bezprozvanny, I .
ANNUAL REVIEW OF PHYSIOLOGY, 2001, 63 :847-869
[9]  
Dayan P, 2001, THEORETICAL NEUROSCI
[10]   Plasticity in the intrinsic excitability of cortical pyramidal neurons [J].
Desai, NS ;
Rutherford, LC ;
Turrigiano, GG .
NATURE NEUROSCIENCE, 1999, 2 (06) :515-520