The impact of HIV on naive T-cell homeostasis

被引：43

作者：

Grossman, Z ^{[1
]}

Paul, WE

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel

[2] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 09期

关键词：

D O I：

10.1038/79667

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Correlational data and mathematical modeling suggest that increased division rate of naive T cells, not reduced thymic output, lowers the frequency of original thymic emigration among these cells in HIV infected individuals. But are there alternate explanations for these data? (pages 1036-1042). © 2000 Nature America Inc.

引用

页码：976 / 977

页数：2

共 15 条

[1] [Anonymous], 1999, SCIENCE, DOI DOI 10.1126/SCIENCE.284.5414.555A
[2] ASCHER MS, 1988, CLIN EXP IMMUNOL, V73, P165
[3] Changes in thymic function with age and during the treatment of HIV infection
Douek, DC
McFarland, RD
Keiser, PH
Gage, EA
Massey, JM
Haynes, BF
Polis, MA
Haase, AT
Feinberg, MB
Sullivan, JL
Jamieson, BD
Zack, JA
Picker, LJ
Koup, RA
[J]. NATURE, 1998, 396 (6712) : 690 - 695
[4] Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts
Goldrath, AW
Bevan, MJ
[J]. IMMUNITY, 1999, 11 (02) : 183 - 190
[5] Ongoing HIV dissemination during HAART
Grossman, Z
Polis, M
Feinberg, MB
Grossman, Z
Levi, I
Jankelevich, S
Yarchoan, R
Boon, J
de Wolf, F
Lange, JMA
Goudsmit, J
Dimitrov, DS
Paul, WE
[J]. NATURE MEDICINE, 1999, 5 (10) : 1099 - 1104
[6] T-cell homeostasis in HIV infection is neither failing nor blind: Modified cell counts reflect an adaptive response of the host
Grossman, Z
Herberman, RB
[J]. NATURE MEDICINE, 1997, 3 (05) : 486 - 490
[7] Multiple modes of cellular activation and virus transmission in HIV infection: A role for chronically and latently infected cells in sustaining viral replication
Grossman, Z
Feinberg, MB
Paul, WE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) : 6314 - 6319
[8] Phenotypic and functional separation of memory and effector human CD8(+) T cells
Hamann, D
Baars, P
Rep, MHG
Hooibrink, B
KerkhofGarde, SR
Klein, MR
vanLier, RAW
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (09) : 1407 - 1418
[9] T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)
Hazenberg, MD
Stuart, JWTC
Otto, SA
Borleffs, JCC
Boucher, CAB
de Boer, RJ
Miedema, F
Hamann, D
[J]. BLOOD, 2000, 95 (01) : 249 - 255
[10] Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection
Hazenberg, MD
Otto, SA
Stuart, JWTC
Verschuren, MCM
Borleffs, JCC
Boucher, CAB
Coutinho, RA
Lange, JMA
De Wit, TFR
Tsegaye, A
Van Dongen, JJM
Hamann, D
De Boer, RJ
Miedema, F
[J]. NATURE MEDICINE, 2000, 6 (09) : 1036 - 1042

← 1 2 →