Factors associated with relative rates of antimicrobial resistance among Streptococcus pneumoniae in the United States:: Results from the TRUST Surveillance Program (1998-2002)

被引:137
作者
Karlowsky, JA
Thornsberry, C
Jones, ME
Evangelista, AT
Critchley, IA
Sahm, DF
机构
[1] Focus Technol, Herndon, VA 20171 USA
[2] Focus Technol, Franklin, TN USA
[3] Focus Technol, Hilversum, Netherlands
[4] Ortho McNeil Pharmaceut, Raritan, NJ USA
关键词
D O I
10.1086/374052
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To identify factors associated with antimicrobial resistance, data were analyzed from 27,828 isolates of Streptococcus pneumoniae submitted to the Tracking Resistance in the United States Today ( TRUST) surveillance program during 4 consecutive respiratory seasons. From the 1998-1999 season to the 2001-2002 season, the prevalence of azithromycin resistance increased by 4.8% to 27.5%, the prevalence of penicillin resistance increased by 3.7% to 18.4%, the prevalence of ceftriaxone resistance increased by 0.5% to 1.7%, and the prevalence of levofloxacin resistance increased by 0.3% to 0.9%. Isolates recovered from patients <18 years of age and lower respiratory tract specimens had elevated rates of penicillin, azithromycin, and trimethoprimsulfamethoxazole resistance (P<.00001); penicillin resistance correlated with coresistance to trimethoprimsulfamethoxazole (87.3%), azithromycin (76.3%), ceftriaxone ( 9.1%), and levofloxacin (1.3%) (P<.00001). Only 62 (0.2%) of 27,828 isolates were concurrently resistant to penicillin and levofloxacin. Minimum inhibitory concentrations (MICs) of penicillin correlated strongly with MICs of ceftriaxone (R-2=0.90), trimethoprimsulfamethoxazole (R-2=0.53), and azithromycin (R-2=0.41). Patient age, specimen source, and penicillin resistance were factors associated with antimicrobial resistance, particularly for nonfluoroquinolone antimicrobial agents.
引用
收藏
页码:963 / 970
页数:8
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