The influence of co-morbidity on health-related quality of life in asthma and COPD patients

被引:100
作者
Wijnhoven, HAH
Kriegsman, DMW
Hesselink, AE
de Haan, M
Schellevis, FG
机构
[1] Free Univ Amsterdam, Med Ctr, EMGO Inst, NL-1081 BT Amsterdam, Netherlands
[2] NIVEL, Utrecht, Netherlands
[3] Free Univ Amsterdam, Med Ctr, Dept Gen Practice, NL-1081 BT Amsterdam, Netherlands
关键词
asthma; COPD; lung diseases; obstructive; comorbidity; quality of life;
D O I
10.1053/rmed.2002.1463
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
This study examines the association between somatic co-morbidity and both general and disease-specific health-related quality of life (HRQoL) in patients with asthma and chronic obstructive pulmonary disease (COPD). A cross-sectional analysis was done among 161 COPD patients and 395 asthma patients, aged 40-75 years, recruited from general practice. In the total study population, 47% had no, 32% had one, and 21% had two or more somatic co-morbid conditions, with no significant differences between asthma and COPD patients. Co-morbidity appeared to be associated with poor disease-specific HRQoL in asthma [odds ratio (OR) = 2.08 (1.37-3.18)] and with poor general HRQoL in asthma [OR = 2.96 (1.93-4.53)] and COPD [1.81 (0.91-3.60)] patients. Poorest HRQoL was found in patients with more than one co-morbid condition. Cardiac disease and hypertension were associated with poor disease-specific HRQoL in asthma. Of all co-morbid conditions, musculoskeletal disorders were most strongly associated with poor general HRQoL. Cardiac disease was found to be associated with general and disease-specific HRQoL in asthma but not in COPD. In studies on patients with asthma or COPD aged 40-75 years, co-morbidity should be treated as a determinant of HRQoL. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:468 / 475
页数:8
相关论文
共 30 条
[1]
[Anonymous], 1987, AM REV RESPIR DIS, V136, P1285
[2]
HEALTH-RELATED QUALITY-OF-LIFE AMONG PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE [J].
CURTIS, JR ;
DEYO, RA ;
HUDSON, LD .
THORAX, 1994, 49 (02) :162-170
[3]
THE DUTCH VERSION OF THE NOTTINGHAM HEALTH PROFILE - INVESTIGATIONS OF PSYCHOMETRIC ASPECTS [J].
ERDMAN, RAM ;
PASSCHIER, J ;
KOOIJMAN, M ;
STRONKS, DL .
PSYCHOLOGICAL REPORTS, 1993, 72 (03) :1027-1035
[4]
Chronic obstructive pulmonary disease stage and health-related quality of life [J].
Ferrer, M ;
Alonso, J ;
Morera, J ;
Marrades, RM ;
Khalaf, A ;
Aguar, MC ;
Plaza, V ;
Prieto, L ;
Antó, JM .
ANNALS OF INTERNAL MEDICINE, 1997, 127 (12) :1072-1079
[5]
Association of comorbidity with disability in older women: The Women's Health and Aging Study [J].
Fried, LP ;
Bandeen-Roche, K ;
Kaser, JD ;
Guralnik, JM .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 1999, 52 (01) :27-37
[6]
Differences in mortality between patients attending the emergency room services for asthma and chronic obstructive pulmonary disease [J].
Garcia-Aymerich, J ;
Sunyer, J ;
Domingo-Salvany, A ;
Mcfarlane, D ;
Montellà, N ;
Pérez, G ;
Antó, JM .
RESPIRATORY MEDICINE, 1999, 93 (11) :822-826
[7]
GEIJER RMM, 1997, HUISARTS WET, V40, P416
[8]
HUNT SM, 1985, J ROY COLL GEN PRACT, V35, P185
[9]
Co-morbidity contributes to predict mortality of patients with chronic obstructive pulmonary disease [J].
Incalzi, RA ;
Fuso, L ;
De Rosa, M ;
Forastiere, F ;
Rapiti, E ;
Nardecchia, B ;
Pistelli, R .
EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (12) :2794-2800
[10]
Determinants of health-related quality of life in patients with chronic obstructive pulmonary disease [J].
Ketelaars, CAJ ;
Schlosser, MAG ;
Mostert, R ;
AbuSaad, HH ;
Halfens, RJG ;
Wouters, EFM .
THORAX, 1996, 51 (01) :39-43