Adjuvant Chemoradiation Therapy in Gallbladder Cancer

Background and Objectives: Gallbladder cancel is a relatively uncommon gastrointestinal malgnancy Indications for adjuvant chemotadiation therapy after surgical resection have not yet been determined We aimed this study to elucidate the effectiveness of adjuvant chemoradiation therapy according TNM stage for gallbladder cancer Methods: Between March 2001 and March 2009, 100 patients with gallbladder cancel underwent surgical resection We divided the patients according to TNM sine. and subdivided further according to whether adjuvant chemoradiation therapy was added or not The clinicopathologic factors recurrence and survival were retrospectively analyzed Results: Patients with gallbladder cancel at T2N0M0. T2N1M0. T3N0M0. and T3N1M0 stages were enrolled in this study Among the four stages. the two lymph node-neaative stages (T2N0M. and T3N0M0) did not show any earn in survival by adding adjuvant chemorachation therapy Conversely, the remaming lymph node-positive stages (T2N1M0 and T3N1M0) showed gain in disease-free survival, and the lymph node-positive T2 stage (T2N1M0) showed gain in disease-specific survival In patients with lymph node-positive T21T3 GB cancers. adjuvant chemoradiation therapy was an independent proenostic factor for survival Conclusions: Adjuvant chemoradiation therapy is recommended for lymph node-posit we T2/T3 gallbladder cancer following surgical resection J Slug Oncol 2010.102 87-93 (C) 2010 Wiley-Liss. Inc