A novel isoxazole-based scaffold for combinatorial chemistry

被引：42

作者：

Batra, S ^{[1
]}

Rastogi, SK ^{[1
]}

Kundu, B ^{[1
]}

Patra, A ^{[1
]}

Bhaduri, AP ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 31期

关键词：

combinatorial chemistry; 5-isoxazolecarboxaldehyde; SPOS; Baylis-Hillman reaction; Wittig reaction;

D O I：

10.1016/S0040-4039(00)00951-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel isoxazole-based scaffold has been identified for the generation of combinatorial libraries using solid-phase methods. This scaffold has been utilized to afford high value synthetic intermediates through Baylis-Hillman reaction, Wittig reaction, nitroaldol condensation, and imine and oxime formation. The utility of the scaffold has been demonstrated by synthesizing a small library of 32 isoxazole substituted gamma-amino alcohol using four activated alkenes and eight amines. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5971 / 5974

页数：4

共 9 条

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