6,7-Dimethoxy-4-methylquinoline has been converted in nine steps into the sulfur-containing pyrrolo[4,3,2-de]quinoline marine alkaloid isobatzelline B. This constitutes the first total synthesis of an alkaloid of the group which contains a methylthio substituent (C) 1998 Elsevier Science Ltd. All rights reserved.
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BARROWS LR, 1993, ANTI-CANCER DRUG DES, V8, P333