Time-controlled desorption of ultrathin polymer films triggered by enzymatic degradation

被引：81

作者：

Serizawa, T ^{[1
]}

Yamaguchi, M ^{[1
]}

Akashi, M ^{[1
]}

机构：

[1] Kagoshima Univ, Grad Sch Sci & Engn, Dept Nanostructured & Adv Mat, Kagoshima 8900065, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 10期

关键词：

DNA; enzyme catalysis; layered compounds; polymers; ultrathin films;

D O I：

10.1002/anie.200390293

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Degrading films: Surface-component-dependent and time-controlled degradation of a layer-by-layer (LbL) assembly comprising DNA and a cationic synthetic polymer is demonstrated through enzymatic hydrolysis by DNase - (see picture). The negatively charged enzyme is preserved on the cationic polymer surface in an inactive state, and changes in the concentrations of the essential Mg2+ and Ca2+ ions are used to control the activity of the enzyme, and thus control the desorption of the assembly.

引用

页码：1115 / 1118

页数：4

共 28 条

[1]

[Anonymous], PROTEIN ARCHITECTURE

[2]

Polyvalent hydrogen-bonding functionalization of ultrathin hyperbranched films on polyethylene and gold [J].