Effects of precipitation conditions on the membrane morphology and permeation characteristics

被引：41

作者：

Lin, DT

Cheng, LP

Kang, YJ

Chen, LW

Young, TH ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Ctr Biomed Engn, Taipei 10016, Taiwan

[2] Natl Taiwan Univ, Coll Med, Dept Lab Med, Taipei 10016, Taiwan

[3] Tamkang Univ, Dept Chem Engn, Taipei, Taiwan

[4] Natl Taiwan Univ, Dept Chem Engn, Taipei 10764, Taiwan

来源：

JOURNAL OF MEMBRANE SCIENCE | 1998年 / 140卷 / 02期

关键词：

asymmetric membranes; particulate membranes; glucose; insulin; albumin; immunoglobulins;

D O I：

10.1016/S0376-7388(97)00281-0

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The permeability and permselectivity of asymmetric and particulate membranes towards glucose and proteins of various molecular sizes were studied, It was found that the skin layer of asymmetric membranes was permeable to glucose and insulin but effectively prevent the permeation of immunoglobulins. This result parallels our interest for the development of artificial pancreas. It was also found that skinless particulate membranes exhibited not only high permeation rates with respect to albumin and immunoglobulins but also good selectivity between these components. Thus, particulate membranes has the potential to be used in separating albumin from immunoglobulins for treating disorders related to immunoglobulin abnormalities. (C) 1998 Elsevier Science B.V.

引用

页码：185 / 194

页数：10

共 35 条

[1] LONG-TERM PLASMA-GLUCOSE NORMALIZATION IN EXPERIMENTAL DIABETIC RATS WITH MACROENCAPSULATED IMPLANTS OF BENIGN HUMAN INSULINOMAS [J].