Gene silencing: Two faces of SIR2

被引：38

作者：

Gottschling, DE ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 19期

关键词：

D O I：

10.1016/S0960-9822(00)00714-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are still many mysteries surrounding how silenced regions of the eukaryotic genome are created and maintained. But recent discoveries about the most evolutionarily conserved silencing protein, Sir2p, have provided new mechanistic insights into these processes. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：R708 / R711

页数：4

共 25 条

[1] Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2
Afshar, G
Murnane, JP
[J]. GENE, 1999, 234 (01) : 161 - 168
[2] THE SIR2 GENE FAMILY, CONSERVED FROM BACTERIA TO HUMANS, FUNCTIONS IN SILENCING, CELL-CYCLE PROGRESSION, AND CHROMOSOME STABILITY
BRACHMANN, CB
SHERMAN, JM
DEVINE, SE
CAMERON, EE
PILLUS, L
BOEKE, JD
[J]. GENES & DEVELOPMENT, 1995, 9 (23) : 2888 - 2902
[3] Braunstein M, 1996, MOL CELL BIOL, V16, P4349
[4] TRANSCRIPTIONAL SILENCING IN YEAST IS ASSOCIATED WITH REDUCED NUCLEOSOME ACETYLATION
BRAUNSTEIN, M
ROSE, AB
HOLMES, SG
ALLIS, CD
BROACH, JR
[J]. GENES & DEVELOPMENT, 1993, 7 (04) : 592 - 604
[5] Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
Frye, RA
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 260 (01) : 273 - 279
[6] A NEW ROLE FOR A YEAST TRANSCRIPTIONAL SILENCER GENE, SIR2, IN REGULATION OF RECOMBINATION IN RIBOSOMAL DNA
GOTTLIEB, S
ESPOSITO, RE
[J]. CELL, 1989, 56 (05) : 771 - 776
[7] HENIKOFF S., 2000, BIOCHIM BIOPHYS ACTA, V1470, P1
[8] Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S
Armstrong, CM
Kaeberlein, M
Guarente, L
[J]. NATURE, 2000, 403 (6771) : 795 - 800
[9] The silencing protein SIR2 and its homologs are MAD-dependent protein deacetylases
Landry, J
Sutton, A
Tafrov, ST
Heller, RC
Stebbins, J
Pillus, L
Sternglanz, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) : 5807 - 5811
[10] Lehninger A.L., 1993, PRINCIPLES BIOCH, P1013

← 1 2 3 →