FOXP3: Not just for regulatory T cells anymore

被引：133

作者：

Ziegler, Steven F. ^{[1
]}

机构：

[1] Benaroya Res Inst, Program Immunol, Seattle, WA 98101 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2007年 / 37卷 / 01期

关键词：

FOXP3; NFAT; regulatory T cells;

D O I：

10.1002/eji.200636929

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The forkhead family transcription factor FOXP3 has been shown to be critical for the development and function of CD4(+)CD25(+) regulatory T cells. Recently, FOXP3 expression has been shown to be induced upon activation of human CD4(+) T cells. A new report in this issue of the European Journal of Immunology shows that expression of FOXP3 in activated T cell leads to hyporesponsiveness, but not necessarily to acquisition of suppressor function. This finding suggests a new role for FOXP3 in human CD4+ T cells: down-modulating responses to TCR-mediated stimulation.

引用

页码：21 / 23

页数：3

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