Notch3, another Notch in T cell development

被引：30

作者：

Bellavia, D

Campese, AF

Vacca, A

Gulino, A

Screpanti, I

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med & Pathol, I-00161 Rome, Italy

[2] Univ Roma Tor Vergata, Ist Pasteur, Fondaz Cenci, Bolognetti Fdn, I-00161 Rome, Italy

来源：

SEMINARS IN IMMUNOLOGY | 2003年 / 15卷 / 02期

关键词：

E2A; NF-kappa B; Notch3; pre-TCR; thymus;

D O I：

10.1016/S1044-5323(03)00007-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-kappaB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：107 / 112

页数：6

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