Cognition-enhancing and neuroprotective effects of hederacolchiside-E from Pulsatilla koreana

被引:29
作者
Han, Chang-Kyun
Choi, Won Rack
Oh, Ki-Bong
机构
[1] Seoul Natl Univ, Dept Agr Biotechnol, Seoul 151921, South Korea
[2] SK Chem, Life Sci R&D Ctr, Suwon, Gyeonggi, South Korea
关键词
D O I
10.1055/s-2007-981530
中图分类号
Q94 [植物学];
学科分类号
071001 [植物学];
摘要
The root extract of Pulsatilla koreana (Ranunculaceae) has been found to have prominent abilities to reverse scopolamine-induced cognitive impairment in rats, and to increase the viability of human neuroblastoma SK-N-SH cells incubated with amyloid-beta peptide (1-42) [AP (1-42)]. In vivo and in vitro activity-guided fractionation studies using solvent-partitioning and subsequent chromatographic separations led to the isolation of hederacolchiside-E, an oleanolic glycoside, as an active ingredient. Administration of hederacolchiside-E (30 and 60 mg/kg body weight, p.o.) increased the step-through latency time in the passive avoidance test as efficiently as tacrine (30 mg/kg, p.o.). The neuroprotective effect of hederacolchiside-E on SK-N-SH cells against the toxicity of AP (1-42) was comparable to that of catechin. These data suggest that hederacolchiside-E might be a good therapeutic candidate for the treatment of Alzheimer's disease.
引用
收藏
页码:665 / 669
页数:5
相关论文
共 20 条
[1]
Memory enhancing and neuroprotective effects of selected ginsenosides [J].
Bao, HY ;
Zhang, J ;
Yeo, SJ ;
Myung, CS ;
Kim, HM ;
Kim, JM ;
Park, JH ;
Cho, JS ;
Kang, JS .
ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (03) :335-342
[2]
Synergistic protection of PC12 cells from β-amyloid toxicity by resveratrol and catechin [J].
Conte, A ;
Pellegrini, S ;
Tagliazucchi, D .
BRAIN RESEARCH BULLETIN, 2003, 62 (01) :29-38
[3]
Neuropsychiatric aspects of Alzheimer's disease: The cholinergic hypothesis revisited [J].
Cummings, JL ;
Kaufer, D .
NEUROLOGY, 1996, 47 (04) :876-883
[4]
Method for measuring neurotoxicity of aggregating polypeptides with the MTT assay on differentiated neuroblastoma cells [J].
Datki, Z ;
Juhász, A ;
Gálfi, M ;
Soós, K ;
Papp, R ;
Zádori, D ;
Penke, B .
BRAIN RESEARCH BULLETIN, 2003, 62 (03) :223-229
[5]
DEKANOSIDZE GE, 1984, KHIM PRIR SOEDIN+, P747
[6]
DEKANOSIDZE GE, 1970, KHIM PRIR SOEDIN, V3, P484
[7]
DILTS SL, 1967, J PHARMACOL EXP THER, V158, P279
[8]
Acute anti-inflammatory activity of four saponins isolated from ivy:: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema [J].
Gepdiremen, A ;
Mshvildadze, V ;
Süleyman, H ;
Elias, R .
PHYTOMEDICINE, 2005, 12 (6-7) :440-444
[9]
β-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo:: Involvement of the p38MAPK pathway [J].
Giovannini, MG ;
Scali, C ;
Prosperi, C ;
Bellucci, A ;
Vannucchi, MG ;
Rosi, S ;
Pepeu, G ;
Casamenti, F .
NEUROBIOLOGY OF DISEASE, 2002, 11 (02) :257-274
[10]
Antioxidant activity of saponins isolated from ivy:: α-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F [J].
Gülçin, I ;
Mshvildadze, V ;
Gepdiremen, AA ;
Elias, R .
PLANTA MEDICA, 2004, 70 (06) :561-563