An anatomically based frequency-place map for the mouse cochlea

被引:66
作者
Ou, HC [1 ]
Harding, GW [1 ]
Bohne, BA [1 ]
机构
[1] Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA
关键词
mouse; noise exposure; permanent hearing loss; auditory brainstem response; quantitative histopathology; frequency-place map;
D O I
10.1016/S0378-5955(00)00082-4
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
An anatomically based frequency-place map was created for the mouse using C57BL/CBA F1 hybrids by matching noise-induced lesions in the organ of Corti with permanent hearing losses as determined by auditory brainstem response (ABR) thresholds. Twenty-six mice developed 'notched' ABR threshold shifts after exposure to an octave band of noise with a center frequency of 2 kHz at 120 dB SPL for 24 h, 4 kHz at 110 dB SPL for 4 h or 8 kHz at 100 dB SPL for 1 or 2 h. ABR thresholds were determined at several intervals post-exposure until thresholds stabilized (14-27 days). Once thresholds had stabilized, the mice were killed and their cochleas were prepared for phase-contrast microscopic examination as plastic-embedded flat preparations. Hair cell loss, stereocilia damage, and myelinated nerve fiber degeneration as a function of percentage distance from the cochlear apex were determined. Frequency-position matches could be made for 22 of the 26 mice by correlating areas of hair cell loss/stereocilia damage with permanent changes in ABR thresholds. These frequency-position data were fitted with the equation: % Distance from apex = 56.6 log (f(Hz))-179.1; r(2) = 0.810. This frequency-place function agrees well with Ehret's (1975) theoretical function based on critical bands and masked auditory thresholds. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:123 / 129
页数:7
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