Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope

被引：44

作者：

Goulder, PJR

Lechner, F

Klenerman, P

McIntosh, K

Walker, BD

机构：

[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA

[2] Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA

[3] John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DU, England

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 16期

关键词：

D O I：

10.1128/JVI.74.16.7694-7697.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA B7-restricted epitope in nucleoprotein (NP) was detectable in four healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8+ T cells.

引用

页码：7694 / 7697

页数：4