Viral recognition by Toll-like receptors

被引：183

作者：

Barton, Gregory M. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Div Immunol, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

SEMINARS IN IMMUNOLOGY | 2007年 / 19卷 / 01期

关键词：

Toll-like receptors; viral recognition; innate immunity; self/non-self-discrimination;

D O I：

10.1016/j.smim.2007.01.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) have evolved to recognize conserved features of microbial pathogens, including bacteria, viruses, fungi, and protozoa. Among these pathogen classes, viruses are particularly vexing, as they generally lack any uniquely foreign features that easily distinguish them from the host. Consequently, a number of TLR family members have evolved to recognize various forms of viral nucleic acid. The emergence of this specificity has interesting implications for how we view the evolution of viral genomes. In this review, I discuss the various strategies used by TLRs to recognize viruses as well as the experimental evidence implicating TLRs in viral immunity. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：33 / 40

页数：8

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