Novel IgCAM, MDGA1, expressed in unique cortical area- and layer-specific patterns and transiently by distinct forebrain populations of Cajal-Retzius neurons

被引:31
作者
Takeuchi, Akihide [1 ]
Hamasaki, Tadashi [1 ]
Litwack, E. David [1 ]
O'Leary, Dennis D. M. [1 ]
机构
[1] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA
关键词
barrels; cadherins; cortical area patterning; cortical lamination; COUP-TF1; neuronal migration; Reelin; ROR ss;
D O I
10.1093/cercor/bhl064
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The laminar and area patterning of the mammalian neocortex are two organizing principles that define its functional architecture. Members of the immunoglobulin (1g) superfamily of cell adhesion molecules influence neural development by regulating cell adhesion, migration, and process growth. Here we describe the dynamic expression of the unique Ig-containing cell adhesion molecule, MAM domain-containing glycosylphosphatidylinositol anchor 1 (MDGA1), during forebrain development in mice and compare it with other markers. We show that MDGA1 is a layer-specific marker and an area-specific marker, being expressed in layers 2/3 throughout the neocortex, but within the primary somatosensory area (Sl), MDGAI is also uniquely expressed in layers 4 and 6a. Comparisons with other markers, including cadherins, serotonin, cytochrome oxidase, RORP, and COUP-TF1, reveal unique features of patterned expression of MDGA1 within cortex and S1 barrels. Further, our findings indicate that at earlier stages of development, MDGA1 is expressed by Reelin- and Tbr1-positive Caial-Retzius neurons that originate from multiple sources outside of neocortex and emigrate into it. At even earlier stages, MDGA1 is expressed by the earliest diencephalic and mesencephalic neurons, which appear to migrate from a MDGA1-positive domain of progenitors in the diencephalon and form a "preplate." These findings show that MDGAI is a unique marker for studies of cortical lamination and area patterning and together with recent reports suggest that MDGA1 has critical functions in forebrain/midbrain development.
引用
收藏
页码:1531 / 1541
页数:11
相关论文
共 49 条
[1]   Area- and lamina-specific organization of a neuronal subpopulation defined by expression of latexin in the rat cerebral cortex [J].
Arimatsu, Y ;
Kojima, M ;
Ishida, M .
NEUROSCIENCE, 1999, 88 (01) :93-105
[2]   DEVELOPMENT OF THE ENDOPIRIFORM NUCLEUS AND THE CLAUSTRUM IN THE RAT-BRAIN [J].
BAYER, SA ;
ALTMAN, J .
NEUROSCIENCE, 1991, 45 (02) :391-412
[3]   Multiple origins of Cajal-Retzius cells at the borders of the developing pallium [J].
Bielle, F ;
Griveau, A ;
Narboux-Nême, N ;
Vigneau, S ;
Sigrist, M ;
Arber, S ;
Wassef, M ;
Pierani, A .
NATURE NEUROSCIENCE, 2005, 8 (08) :1002-1012
[4]   Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding [J].
Bishop, KM ;
Garel, S ;
Nakagawa, Y ;
Rubenstein, JLR ;
O'Leary, DDM .
JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 457 (04) :345-360
[5]  
Bishop KM, 2002, J NEUROSCI, V22, P7627
[6]   Regulation of area identity in the mammalian neocortex by Emx2 and Pax6 [J].
Bishop, KM ;
Goudreau, G ;
O'Leary, DDM .
SCIENCE, 2000, 288 (5464) :344-349
[7]  
Brodmann K., 1909, LOKALISATIONSLEHRE G
[8]  
CHENN A, 1997, MOL CELL APPROACHES
[9]   EARLY DETERMINATION OF A MOUSE SOMATOSENSORY CORTEX MARKER [J].
COHENTANNOUDJI, M ;
BABINET, C ;
WASSEF, M .
NATURE, 1994, 368 (6470) :460-463
[10]   A PROTEIN RELATED TO EXTRACELLULAR-MATRIX PROTEINS DELETED IN THE MOUSE MUTANT REELER [J].
DARCANGELO, G ;
MIAO, GG ;
CHEN, SC ;
SOARES, HD ;
MORGAN, JI ;
CURRAN, T .
NATURE, 1995, 374 (6524) :719-723