A convenient one-pot synthesis of trisubstituted 1,3,5-triazines through intermediary amidinothioureas

被引：25

作者：

Kaila, Jitendra C. ^{[1
]}

Baraiya, Arshi B. ^{[1
]}

Pandya, Amit N. ^{[1
]}

Jalani, Hitesh B. ^{[1
]}

Sudarsanam, V. ^{[1
]}

Vasu, Kamala K. ^{[1
]}

机构：

[1] BV Patel Pharmaceut Educ & Res Dev PERD Ctr, Dept Med Chem, Ahmadabad 380054, Gujarat, India

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 11期

关键词：

Thiophile; 1,3,5-Triazines; Amidinothioureas; Carbamidines; SUBSTITUTED GUANIDINES; ANTITUMOR-ACTIVITY; S-TRIAZINES; DERIVATIVES; INHIBITORS; ISOTHIOCYANATES;

D O I：

10.1016/j.tetlet.2010.01.034

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A thiophile-promoted one-pot synthesis of trisubstituted 1,3,5-triazines starting from isothiocyanates, N,N-diethylamidines, and carbamidines has been studied. The reaction proceeds through the formation of intermediary amidinothioureas, which react with carbamidines in the presence of mercury(II) chloride to generate the desired 1,3,5-triazines in good to moderate yields (40-70%). (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1486 / 1489

页数：4

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