Application of infrared attenuated total reflection spectroscopy to in situ analysis of atheromatous plaques in aorta

被引：4

作者：

Nakamura, A ^{[1
]}

Koga, T

Fujimaki, M

Ohki, Y

Sota, T

Lipinska-Kalita, K

Nagae, T

Ishimaru, S

Aizawa, K

机构：

[1] Waseda Univ, Dept Elect Elect & Comp Engn, Shinjuku Ku, Tokyo 1698555, Japan

[2] Waseda Univ, Adv Res Inst Sci & Engn, Shinju Ku, Tokyo 1698555, Japan

[3] Tokyo Med Univ, Dept Surg, Shinjuku Ku, Tokyo 1600023, Japan

[4] Tokyo Med Univ, Dept Physiol, Shinjuku Ku, Tokyo 1608402, Japan

来源：

JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS | 2000年 / 39卷 / 6A期

关键词：

infrared spectroscopy; attenuated total reflection; molecular vibration; spectroscopic diagnosis; biomedical engineering;

D O I：

10.1143/JJAP.39.L490

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Ex vivo infrared attenuated total reflection (ATR) spectroscopic studies have been carried out to observe the accumulation of cholesterol ester in atheromatous plaques. It has been found that ATR spectra can be successfully obtained from the intima side of aorta and give the same information as the transmission spectra. This means, the ATR spectra include information about the chemical composition of atheromatous plaques together with the degree of eventual lesions. We have demonstrated that ATR microspectroscopic measurements can give images of atheromatous plaques distribution and enable in situ observation of the relative amount of accumulated cholesterol ester. The results clearly indicate that the ATR spectroscopy enables spectroscopic diagnoses in vivo as well as in vitro.

引用

页码：L490 / L492

页数：3

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