Apolipoprotein A-IV acts in the brain to inhibit gastric emptying in the rat

被引:37
作者
Okumura, T
Fukagawa, K
Tso, P
Taylor, IL
Pappas, TN
机构
[1] VET AFFAIRS MED CTR, DURHAM, NC 27710 USA
[2] LOUISIANA STATE UNIV, MED CTR, DEPT PHYSIOL, SHREVEPORT, LA 71130 USA
[3] MED UNIV S CAROLINA, DEPT MED, CHARLESTON, SC 29425 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 1996年 / 270卷 / 01期
关键词
enterogastrone; central nervous system;
D O I
10.1152/ajpgi.1996.270.1.G49
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We have very recently shown that intracisternal injection of apolipoprotein A-IV (ape A-IV), a glycoprotein produced in the small intestine by fat, dose-dependently inhibited gastric acid secretion in pylorus-ligated conscious rats. These results suggest that apo A-IV acts centrally as a neuromodulator to inhibit gastric secretion. The present study was carried out to examine the hypothesis that apo A-IV acts centrally to alter gastric emptying. Rats fasted 24 h received intracisternal injection of apo A-IV and a liquid meal by oral intubation under brief isoflurane anesthesia. Gastric emptying of a liquid meal was determined by the phenol red method. Intracisternal injection of apo A-IV inhibited gastric emptying of a liquid meal in a dose-dependent manner (1.0-4.0 mu g). On the other hand, apo A-I in a dose of 4 mu g failed to change gastric emptying. Gastric emptying was not altered by intraperitoneal administration of apo A-IV in a dose of 15 mu g. These results suggest that apoA-IV acts centrally to delay gastric emptying of a liquid meal. Together with our recent finding that apo A-IV acts centrally to inhibit gastric acid secretion, the present study supports our hypothesis that apo A-IV may be involved in lipid-induced inhibition of gastric function.
引用
收藏
页码:G49 / G53
页数:5
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