Colchicine for large pericardial effusion

被引:19
作者
Adler, Y
Guindo, J
Finkelstein, Y
Khouri, A
Assali, A
Bayes-Genis, A
De Luna, AB
机构
[1] Rabin Med Ctr, Coronary Care Unit, Dept Cardiol, IL-49100 Petah Tiqwa, Israel
[2] Hop Santa Creu & Sant Pau, Dept Cardiol, Barcelona, Spain
[3] Rambam Med Ctr, Dept Pediat Cardiol, Haifa, Israel
关键词
pericardial effusion; recurrent pericarditis; colchicine;
D O I
10.1002/clc.4960210220
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
On the basis of our reported experience with colchicine for recurrent pericarditis, we administered colchicine to two patients with large pericardial effusions complicating idiopathic pericarditis. The first was a 26-year-old male who showed clinical deterioration following emergency pericardiocentesis and aspirin (3 g/day) for 10 days; the second was a 2-year-old girl who was unsuccessfully treated with aspirin (100 mg/kg/day) for 2 weeks. followed by corticosteroids for 7 months. Administration of colchicine (1 mg/day) instead of aspirin in the first case, and with a rapid tapering-off of the corticosteroids in the second case, led to complete regression of the pericardial effusion on echocardiography within 1 week and 1 month, respectively. Colchicine was discontinued after 1 month in the first patient and was continued for 6 months in the child. Neither has had a recurrence at 24 and 6 months of follow-up, respectively. No side effects of colchicine were observed. We conclude that colchicine may be effective in the treatment of large pericardial effusion when therapy with nonsteroidal anti-inflammatory drugs and/or corticosteroids fails.
引用
收藏
页码:143 / 144
页数:2
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