c-TERMINAL AGRIN FRAGMENT IS INVERSELY RELATED TO NEUROMUSCULAR FATIGUE IN OLDER MEN

被引：30

作者：

Stout, Jeffrey R. ^{[1
]}

Fragala, Maren S. ^{[1
]}

Hoffman, Jay R. ^{[1
]}

Robinson, Edward H. ^{[1
]}

Mccormack, William P. ^{[1
]}

Townsend, Jeremy R. ^{[1
]}

Jatjner, Adam R. ^{[1
]}

Emerson, Nadia S. ^{[1
]}

Oliveira, Leonardo P. ^{[1
]}

Fukuda, David H. ^{[1
]}

机构：

[1] Univ Cent Florida, Coll Educ & Human Performance, Inst Exercise Physiol & Wellness, Orlando, FL 32816 USA

来源：

MUSCLE & NERVE | 2015年 / 51卷 / 01期

关键词：

aging; electromyography; exercise; physiological adaptations; sarcopenia; serum biomarker; PHYSICAL WORKING CAPACITY; THRESHOLD PWCFT; JUNCTION; ADULTS;

D O I：

10.1002/mus.24443

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The aim of this study was to examine the relationship between serum C-terminal agrin fragment (CAF) concentrations and neuromuscular fatigue in older adults. Methods: Twenty-two healthy older men and women volunteered for this study. Resting fasted blood samples were collected and prepared for measurement of serum CAF concentration by a commercially available ELISA kit. The onset of neuromuscular fatigue was measured by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at fatigue threshold (PWCFT) test. Results: A significant inverse correlation for men was observed between CAF and PWCFT (r=-0.602; P=0.05), but not for women (r=0.208; P=0.54). After controlling for age and body mass index, significant correlations (r=-0.69; P=0.042) remained for men, but not for women (r=0.12; P=0.76). Conclusions: These data suggest that serum CAF concentrations were significantly related to the onset of neuromuscular fatigue independent of age and BMI in men only.

引用

页码：132 / 133

页数：2

共 7 条

[1] Fatigue in older adults: an early indicator of the aging process?
Avlund, Kirsten
[J]. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2010, 22 (02) : 100 - 115
[2] Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction
Bolliger, Marc F.
Zurlinden, Andreas
Luescher, Daniel
Buetikofer, Lukas
Shakhova, Olga
Francolini, Maura
Kozlov, Serguei V.
Cinelli, Paolo
Stephan, Alexander
Kistler, Andreas D.
Ruelicke, Thomas
Pelczar, Pawel
Ledermann, Birgit
Fumagalli, Guido
Gloor, Sergio M.
Kunz, Beat
Sonderegger, Peter
[J]. JOURNAL OF CELL SCIENCE, 2010, 123 (22) : 3944 - 3955
[3] Remodeling of the neuromuscular junction precedes sarcopenia related alterations in myofibers
Deschenes, Michael R.
Roby, Mackenzie A.
Eason, Margaret K.
Harris, M. Brennan
[J]. EXPERIMENTAL GERONTOLOGY, 2010, 45 (05) : 389 - 393
[4] ESTIMATING PHYSICAL WORKING CAPACITY AND TRAINING CHANGES IN THE ELDERLY AT THE FATIGUE THRESHOLD (PWCFT)
DEVRIES, HA
BRODOWICZ, GR
ROBERTSON, LD
SVOBODA, MD
SCHENDEL, JS
TICHY, AM
TICHY, MW
[J]. ERGONOMICS, 1989, 32 (08) : 967 - 977
[5] C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction
Drey, M.
Sieber, C. C.
Bauer, J. M.
Uter, W.
Dahinden, P.
Fariello, R. G.
Vrijbloed, J. W.
[J]. EXPERIMENTAL GERONTOLOGY, 2013, 48 (01) : 76 - 80
[6] Physical working capacity at fatigue threshold (PWCFT) is associated with sarcopenia-related body composition and measures of functionality in older adults
Emerson, Nadia S.
Fukuda, David H.
Stout, Jeffrey R.
Robinson, Edward H., IV
McCormack, William P.
Scanlon, Tyler C.
Warren, Ashlee M.
Wells, Adam J.
Gonzalez, Adam M.
Mangine, Gerald T.
Fragala, Maren S.
Hoffman, Jay R.
[J]. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2014, 59 (02) : 300 - 304
[7] Biomarkers of muscle quality: N-terminal propeptide of type III procollagen and C-terminal agrin fragment responses to resistance exercise training in older adults
Fragala, Maren S.
Jajtner, Adam R.
Beyer, Kyle S.
Townsend, Jeremy R.
Emerson, Nadia S.
Scanlon, Tyler C.
Oliveira, Leonardo P.
Hoffman, Jay R.
Stout, Jeffrey R.
[J]. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2014, 5 (02) : 139 - 148

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