Human intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin H synthase 2 expression and prostaglandin E2 and F2α production

被引：67

作者：

Laurent, F

Kagnoff, MF

Savidge, TC

Naciri, M

Eckmann, L

机构：

[1] Univ Calif San Diego, Dept Med 0623D, Lab Mucosal Immunol, La Jolla, CA 92093 USA

[2] Babraham Inst, Dept Cellular Physiol, Cambridge CB2 4AT, England

[3] INRA, Ctr Tours, Lab Protozool, F-37380 Nouzilly, France

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 04期

关键词：

D O I：

10.1128/IAI.66.4.1787-1790.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of cryptosporidiosis, but their cellular sources and mechanisms of induction are unclear. Here, we show that C. parvum infection directly activates prostaglandin H synthase 2 expression and prostaglandin E-2 and F-2 alpha production in human intestinal epithelial cells.

引用

收藏

页码：1787 / 1790

页数：4

相关论文

共 25 条

[1]

Argenzio RA, 1996, J PHARMACOL EXP THER, V279, P1109

[2] VILLOUS ATROPHY, CRYPT HYPERPLASIA, CELLULAR INFILTRATION, AND IMPAIRED GLUCOSE-NA ABSORPTION IN ENTERIC CRYPTOSPORIDIOSIS OF PIGS [J].

ARGENZIO, RA ;

LIACOS, JA ;

LEVY, ML ;

MEUTEN, DJ ;

LECCE, JG ;

POWELL, DW .

GASTROENTEROLOGY, 1990, 98 (05) :1129-1140

[3] PROSTANOIDS INHIBIT INTESTINAL NACL ABSORPTION IN EXPERIMENTAL PORCINE CRYPTOSPORIDIOSIS [J].

ARGENZIO, RA ;

LECCE, J ;

POWELL, DW .

GASTROENTEROLOGY, 1993, 104 (02) :440-447

[4] PROFILES OF EICOSANOID PRODUCTION BY SUPERFICIAL AND PROLIFERATIVE COLONIC EPITHELIAL-CELLS AND SUB-EPITHELIAL COLONIC TISSUE [J].

CRAVEN, PA ;

DERUBERTIS, FR .

PROSTAGLANDINS, 1986, 32 (03) :387-399

[5] Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria - Bacterial entry induces epithelial prostaglandin H synthase-2 expression and prostaglandin E-2 and F-2 alpha production [J].

Eckmann, L ;

Stenson, WF ;

Savidge, TC ;

Lowe, DC ;

Barrett, KE ;

Fierer, J ;

Smith, JR ;

Kagnoff, MF .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (02) :296-309

[6] NS-398, A NEW ANTIINFLAMMATORY AGENT, SELECTIVELY INHIBITS PROSTAGLANDIN-G/H SYNTHASE CYCLOOXYGENASE (COX-2) ACTIVITY IN-VITRO [J].

FUTAKI, N ;

TAKAHASHI, S ;

YOKOYAMA, M ;

ARAI, I ;

HIGUCHI, S ;

OTOMO, S .

PROSTAGLANDINS, 1994, 47 (01) :55-59

[7] DUODENAL MORPHOLOGY AND INTENSITY OF INFECTION IN AIDS-RELATED INTESTINAL CRYPTOSPORIDIOSIS [J].

GENTA, RM ;

CHAPPELL, CL ;

WHITE, AC ;

KIMBALL, KT ;

GOODGAME, RW .

GASTROENTEROLOGY, 1993, 105 (06) :1769-1775

[8] HUMAN INTESTINAL CRYPTOSPORIDIOSIS - SECRETORY DIARRHEA AND ENTEROTOXIC ACTIVITY IN CACO-2 CELLS [J].

GUARINO, A ;

CANANI, RB ;

CASOLA, A ;

POZIO, E ;

RUSSO, R ;

BRUZZESE, E ;

FONTANA, M ;

RUBINO, A .

JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (04) :976-983

[9] CRYPTOSPORIDIUM-PARVUM - INVESTIGATION OF SPOROZOITE EXCYSTATION INVIVO AND THE ASSOCIATION OF MEROZOITES WITH INTESTINAL MUCUS [J].

HILL, BD ;

BLEWETT, DA ;

DAWSON, AM ;

WRIGHT, S .

RESEARCH IN VETERINARY SCIENCE, 1991, 51 (03) :264-267

[10] A DISTINCT ARRAY OF PROINFLAMMATORY CYTOKINES IS EXPRESSED IN HUMAN COLON EPITHELIAL-CELLS IN RESPONSE TO BACTERIAL INVASION [J].

JUNG, HC ;

ECKMANN, L ;

YANG, SK ;

PANJA, A ;

FIERER, J ;

MORZYCKAWROBLEWSKA, E ;

KAGNOFF, MF .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (01) :55-65