Crystal Formation in Inflammation

被引：104

作者：

Franklin, Bernardo S. ^{[1
]}

Mangan, Matthew S. ^{[1
,2
]}

Latz, Eicke ^{[1
,2
,3
,4
]}

机构：

[1] Univ Bonn, Univ Hosp, Inst Innate Immun, D-53127 Bonn, Germany

[2] German Ctr Neurodegenerat Dis, D-53175 Bonn, Germany

[3] Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA

[4] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, Ctr Mol Inflammat Res, N-7491 Trondheim, Norway

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 34 | 2016年 / 34卷

关键词：

interleukin-1; cardiovascular diseases; gout; malaria; air pollution; nanotechnology; NECROSIS-FACTOR-ALPHA; CHARCOT-LEYDEN CRYSTALS; INDUCED PULMONARY INFLAMMATION; CHRONIC GRANULOMATOUS-DISEASE; INDUCED LUNG INFLAMMATION; INNATE IMMUNE ACTIVATION; MACROPHAGE FOAM CELLS; NLRP3; INFLAMMASOME; NALP3; AIR-POLLUTION;

D O I：

10.1146/annurev-immunol-041015-055539

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The formation and accumulation of crystalline material in tissues is a hallmark of many metabolic and inflammatory conditions. The discovery that the phase transition of physiologically soluble substances to their crystalline forms can be detected by the immune system and activate innate immune pathways has revolutionized our understanding of how crystals cause inflammation. It is now appreciated that crystals are part of the pathogenesis of numerous diseases, including gout, silicosis, asbestosis, and atherosclerosis. In this review we discuss current knowledge of the complex mechanisms of crystal formation in diseased tissues and their interplay with the nutrients, metabolites, and immune cells that account for crystal-induced inflammation.

引用

页码：173 / 202

页数：30

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