Synthesis of chiral C2-symmetric 1,10-phenanthrolines from naturally occurring monoterpenes

被引：17

作者：

Chelucci, G

Loriga, G

Murineddu, G

Pinna, GA

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

[2] Univ Sassari, Dipartimento Farmaco Chim Tossicol, I-07100 Sassari, Italy

来源：

SYNTHESIS-STUTTGART | 2003年 / 01期

关键词：

nitrogen heterocycles; 1,10-phenanthrolines; nitrogen ligands; bidentate ligands; Michael additions;

D O I：

10.1055/s-2003-36260

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient procedure for the preparation of chiral C,symmetric 1,10-phenanthrolines bearing a chiral framework in the form of a cycloalkeno-condensed substituent in the 2,3- and 8,9-positions of the heterocycle is reported. Starting from the 2-benzyloxycyclohexanone, four 1,10-phenanthrolines derived from (-)-beta-pinene, (+)-alpha-pinene, (-)-isopinocampheol, and (+)-camphor were prepared according to a method based on a double Michael-aza-annulation-aromatization sequence.

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收藏

页码：73 / 78

页数：6

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