Complete regression of a previously untreated melanoma brain metastasis with ipilimumab

被引：58

作者：

Schartz, Noel E. C.

Farges, Cecile ^{[2
]}

Madelaine, Isabelle

Bruzzoni, Heriberto ^{[3
]}

Calvo, Fabien ^{[3
]}

Hoos, Axel ^{[4
]}

Lebbe, Celeste ^{[1
]}

机构：

[1] Univ Paris 07, Hop St Louis, AP HP, Skin Res Ctr,Dept Dermatol,INSERM,U976, F-75475 Paris 10, France

[2] Hop St Louis, AP HP, Dept Radiol, Paris, France

[3] Hop St Louis, AP HP, CIC Ctr Clin Invest, Paris, France

[4] Bristol Myers Squibb Co, Wallingford, CT 06492 USA

来源：

MELANOMA RESEARCH | 2010年 / 20卷 / 03期

关键词：

brain metastasis; ipilimumab; melanoma; VACCINATION; BLOCKADE; RESPONSES; ANTIGEN-4; ANTIBODY;

D O I：

10.1097/CMR.0b013e3283364a37

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anecdotal cases of partial or complete responses have been reported after ipilimumab therapy for stage IV melanoma with brain metastasis treated earlier by surgery or radiosurgery. We report the first case of ipilimumab monotherapy resulting in durable complete remission of untreated, progressive brain metastases in a patient with stage IV melanoma. This case and earlier reports provide support for the further evaluation of ipilimumab in melanoma patients with brain metastasis. Melanoma Res 20:247-250 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：247 / 250

页数：4

共 21 条

[1]

BERMAN D, 2008, J CLIN ONCOL S, V26, pS19

[2]

CHIN K, 2008, ANN ONCOL S, V19, pS8

[3] Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade [J].

Downey, Stephanie G. ;

Klapper, Jacob A. ;

Smith, Franz O. ;

Yang, James C. ;

Sherry, Richard M. ;

Royal, Richard E. ;

Kammula, Udai S. ;

Hughes, Marybeth S. ;

Allen, Tamika E. ;

Levy, Catherine L. ;

Yellin, Michael ;

Nich, Geoffrey ;

White, Donald E. ;

Steinberg, Seth M. ;

Rosenberg, Steven A. .

CLINICAL CANCER RESEARCH, 2007, 13 (22) :6681-6688

[4]

HAMID O, 2008, J CLIN ONCOL S, V26, pS19

[5] CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS [J].

Hodi, F. Stephen ;

Oble, Darryl A. ;

Drappatz, Jan ;

Velazquez, Elsa F. ;

Ramaiya, Nikhil ;

Ramakrishna, Naren ;

Day, Arthur L. ;

Kruse, Andrea ;

Mac Rae, Suzanne ;

Hoos, Axel ;

Mihm, Martin .

NATURE CLINICAL PRACTICE ONCOLOGY, 2008, 5 (09) :557-561

[6] Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients [J].

Hodi, F. Stephen ;

Butler, Marcus ;

Oble, Darryl A. ;

Seiden, Michael V. ;

Haluska, Frank G. ;

Kruse, Andrea ;

MacRae, Suzanne ;

Nelson, Marybeth ;

Canning, Christine ;

Lowy, Israel ;

Korman, Alan ;

Lautz, David ;

Russell, Sara ;

Jaklitsch, Michael T. ;

Ramaiya, Nikhil ;

Chen, Teresa C. ;

Neuberg, Donna ;

Allison, James P. ;

Mihm, Martin C. ;

Dranoff, Glenn .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (08) :3005-3010

[7]

HODI FS, 2008, J CLIN ONCOL S, V26, pS19

[8] Checkpoint blockade in cancer immunotherapy [J].

Korman, AJ ;

Peggs, KS ;

Allison, JP .

ADVANCES IN IMMUNOLOGY, VOL 90: CANCER IMMUNOTHERAPY, 2006, 90 :297-339

[9]

LEBBE C, 2008, ANN ONCOL S, V19, pS8

[10] Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment [J].

Liau, LM ;

Prins, RM ;

Kiertscher, SM ;

Odesa, SK ;

Kremen, TJ ;

Giovannone, AJ ;

Lin, JW ;

Chute, DJ ;

Mischel, PS ;

Cloughesy, TF ;

Roth, MD .

CLINICAL CANCER RESEARCH, 2005, 11 (15) :5515-5525

← 1 2 3 →