Intergenerational transmission of programmed effects: public health consequences

被引：74

作者：

Drake, Amanda J. ^{[1
]}

Liu, Lincoln ^{[1
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, Endocrinol Unit, Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Midlothian, Scotland

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2010年 / 21卷 / 04期

基金：

英国医学研究理事会;

关键词：

INTRAUTERINE GROWTH-RETARDATION; ENDOCRINE DISRUPTOR VINCLOZOLIN; DIETARY-PROTEIN RESTRICTION; LOW-BIRTH-WEIGHT; EPIGENETIC INHERITANCE; DEVELOPMENTAL ORIGINS; GENE-EXPRESSION; TRANSGENERATIONAL INHERITANCE; GLUCOSE-INTOLERANCE; INSULIN-RESISTANCE;

D O I：

10.1016/j.tem.2009.11.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epidemiological studies have shown that the environment experienced in early life can 'programme' susceptibility to later disease. Furthermore, there is increasing evidence that these effects can be transmissible to subsequent generations through non-genomic mechanisms, with profound implications for human populations. Several mechanisms can underpin the intergenerational transmission of the programmed phenotype, including persistence of the abnormal environment across generations, maternal effects and the transmission of epigenetic information through the germline. In this review, we discuss the evidence for these mechanisms in human and animal studies and the potential importance of this field for human health.

引用

页码：206 / 213

页数：8

共 97 条

[1] Placental insufficiency leads to developmental hypertension and mesenteric artery dysfunction in two generations of Sprague-Dawley rat offspring [J].