Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy -: A retrospective study of 19 cases

被引：17

作者：

Berkane, N

Cocheton, JJ

Brehier, D

Merviel, P

Wolf, C

Lefèvre, G

Uzan, S

机构：

[1] Hop Tenon, Serv Gynecol Obstet & Med Reprod, F-75020 Paris, France

[2] Hop Tenon, Serv Med Interne, F-75020 Paris, France

[3] Hop St Antoine, Serv Biochim, Paris, France

[4] Hop Tenon, Serv Biochim, AP HP, F-75970 Paris, France

来源：

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA | 2000年 / 79卷 / 11期

关键词：

cholestasis; maternal and fetal outcome; pregnancy; treatment; ursodeoxycholic acid;

D O I：

10.1034/j.1600-0412.2000.079011941.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective. We studied the clinical and biological effects and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy (TCP). Methods. All cases of ICP treated with ursodeoxycholic acid in our department from January Ist, 1991 to May 31st, 1997 were reviewed. Results. Forty-three patients had ICP, of whom 19 received ursodeoxycholic acid. The first symptoms appeared after a mean of 29.7 weeks of pregnancy (WP). Treatment was started after a mean of 32 WP, and lasted a mean of 28.5 days. Fourteen patients showed a clinical improvement on UDCA, and 11 showed a biological improvement. Two had a biological deterioration with increased liver enzyme concentrations. Conclusions. Ursodeoxycholic acid appears to be an effective treatment for ICP, but further studies are needed to confirm its safety in pregnancy.

引用

页码：941 / 946

页数：6

共 28 条

[1] Intrahepatic cholestasis of pregnancy: Perinatal outcome associated with expectant management [J].