Mammalian fatty acid synthase: Closure on a textbook mechanism?

被引：4

作者：

Leadlay, P ^{[1
]}

Baerga-Ortiz, A ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

CHEMISTRY & BIOLOGY | 2003年 / 10卷 / 02期

关键词：

D O I：

10.1016/S1074-5521(03)00029-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian fatty acid synthase is a classic example of a chain-building multienzyme. A cornerstone of its mechanism has been the obligatory collaboration of two identical subunits, with fatty acyl intermediates transferring between them. Now, fresh evidence has upset this view.

引用

页码：101 / 103

页数：3

共 21 条

[1] 6-DEOXYERYTHRONOLIDE-B SYNTHASE-2 FROM SACCHAROPOLYSPORA-ERYTHRAEA - CLONING OF THE STRUCTURAL GENE, SEQUENCE-ANALYSIS AND INFERRED DOMAIN-STRUCTURE OF THE MULTIFUNCTIONAL ENZYME [J].

BEVITT, DJ ;

CORTES, J ;

HAYDOCK, SF ;

LEADLAY, PF .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 204 (01) :39-49

[2] STRUCTURE AND MECHANISM OF ACTION OF A MULTIFUNCTIONAL ENZYME - FATTY-ACID SYNTHASE [J].

CHANG, SI ;

HAMMES, GG .

ACCOUNTS OF CHEMICAL RESEARCH, 1990, 23 (11) :363-369

[3] AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA [J].

CORTES, J ;

HAYDOCK, SF ;

ROBERTS, GA ;

BEVITT, DJ ;

LEADLAY, PF .

NATURE, 1990, 348 (6297) :176-178

[4] The 1.8 Å crystal structure and active-site architecture of β-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli [J].

Davies, C ;

Heath, RJ ;

White, SW ;

Rock, CO .

STRUCTURE, 2000, 8 (02) :185-195

[5] MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS [J].

DONADIO, S ;

STAVER, MJ ;

MCALPINE, JB ;

SWANSON, SJ ;

KATZ, L .

SCIENCE, 1991, 252 (5006) :675-679

[6] Crystal structure of β-ketoacyl-acyl carrier protein synthase II from E-coli reveals the molecular architecture of condensing enzymes [J].

Huang, WJ ;

Jia, J ;

Edwards, P ;

Dehesh, K ;

Schneider, G ;

Lindqvist, Y .

EMBO JOURNAL, 1998, 17 (05) :1183-1191

[7] The malonyl/acetyltransferase and β-ketoacyl synthase domains of the animal fatty acid synthase can cooperate with the acyl carrier protein domain of either subunit [J].

Joshi, AK ;

Witkowski, A ;

Smith, S .

BIOCHEMISTRY, 1998, 37 (08) :2515-2523

[8] Differential affinity labeling of the two subunits of the homodimeric animal fatty acid synthase allows isolation of heterodimers consisting of subunits that have been independently modified [J].

Joshi, AK ;

Rangan, VS ;

Smith, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (09) :4937-4943

[9]

JOSHI AK, 1993, J BIOL CHEM, V268, P22508

[10] Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro [J].

Joshi, AK ;

Witkowski, A ;

Smith, S .

BIOCHEMISTRY, 1997, 36 (08) :2316-2322

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