Examining Braak's Hypothesis by Imaging Parkinson's Disease

被引：22

作者：

Brooks, David J. ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Ctr Clin Sci, London W12 0NN, England

[2] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Div Neurosci & Mental Hlth, London W12 0NN, England

来源：

MOVEMENT DISORDERS | 2010年 / 25卷 / 03期

关键词：

Parkinson's disease; Braak staging; positron emission tomography; SPECT; magnetic resonance imaging; transcranial sonography; SLEEP BEHAVIOR DISORDER; CARDIAC SYMPATHETIC DENERVATION; MULTIPLE-SYSTEM ATROPHY; SUBSTANTIA-NIGRA; ALZHEIMERS-DISEASE; MICROGLIAL ACTIVATION; DOPAMINE TRANSPORTERS; DYSFUNCTION; DEMENTIA; SPECT;

D O I：

10.1002/mds.22720

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this review, in vivo patterns of structural, metabolic, and neurotransmitter binding changes revealed by imaging in both symptomatic Parkinson's disease (PD) and at-risk subjects are compared with those predicted at different Braak stages. It is concluded that the dysfunction revealed by imaging in PD is only partially in line with the sequential ascending topography of Lewy body pathology reported by Braak, suggesting that neurons in different brain regions are likely to be selectively vulnerable to the presence of intracellular synuclein aggregates. (C) 2010 Movement Disorder Society

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页码：S83 / S88

页数：6

相关论文

共 40 条

[1] Decreased striatal dopaminergic innervation in REM sleep behavior disorder [J].

Albin, RL ;

Koeppe, RA ;

Chervin, RD ;

Consens, FB ;

Wernette, K ;

Frey, KA ;

Aldrich, MS .

NEUROLOGY, 2000, 55 (09) :1410-1412

[2] PK ('peripheral benzodiazepine') - Binding sites in the CNS indicate early and discrete brain lesions: Microautoradiographic detection of [H-3]PK11195 binding to activated microglia [J].

Banati, RB ;

Myers, R ;

Kreutzberg, GW .

JOURNAL OF NEUROCYTOLOGY, 1997, 26 (02) :77-82

[3] Relationship of substantia nigra echogenicity and motor function in elderly subjects [J].

Berg, D ;

Siefker, C ;

Ruprecht-Dörfler, P ;

Becker, G .

NEUROLOGY, 2001, 56 (01) :13-17

[4] Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease - An in vivo positron emission tomographic study [J].

Bohnen, NI ;

Kaufer, DI ;

Ivanco, LS ;

Lopresti, B ;

Koeppe, RA ;

Davis, JG ;

Mathis, CA ;

Moore, RY ;

DeKosky, ST .

ARCHIVES OF NEUROLOGY, 2003, 60 (12) :1745-1748

[5] Motor correlates of occipital glucose hypometabolism in Parkinson's disease without dementia [J].

Bohnen, NI ;

Minoshima, S ;

Giordani, B ;

Frey, KA ;

Kuhl, DE .

NEUROLOGY, 1999, 52 (03) :541-546

[6] Stages in the development of Parkinson's disease-related pathology [J].

Braak, H ;

Ghebremedhin, E ;

Rüb, U ;

Bratzke, H ;

Del Tredici, K .

CELL AND TISSUE RESEARCH, 2004, 318 (01) :121-134

[7] Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease [J].

Brooks, DJ ;

Frey, KA ;

Marek, KL ;

Oakes, D ;

Paty, D ;

Prentice, R ;

Shults, CW ;

Stoessl, AJ .

EXPERIMENTAL NEUROLOGY, 2003, 184 :S68-S79

[8] Non-motor symptoms of Parkinson's disease: diagnosis and management [J].

Chaudhuri, KR ;

Healy, DG ;

Schapira, AHV .

LANCET NEUROLOGY, 2006, 5 (03) :235-245

[9] Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease [J].

Comella, CL ;

Nardine, TM ;

Diederich, NJ ;

Stebbins, GT .

NEUROLOGY, 1998, 51 (02) :526-529

[10] Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease [J].

Courbon, F ;

Brefel-Courbon, C ;

Thalamas, C ;

Alibelli, MJ ;

Berry, I ;

Montastruc, JL ;

Rascol, O ;

Senard, JM .

MOVEMENT DISORDERS, 2003, 18 (08) :890-897

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