Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease

被引：74

作者：

Anello, G

Guéant-Rodriguez, RM

Bosco, P

Guéant, JL

Romano, A

Namour, B

Spada, R

Caraci, F

Pourié, G

Daval, JL

Ferri, R

机构：

[1] Fac Med, URM IFREMER 20, INSERM 0014, EMI, F-54500 Vandoeuvre Les Nancy, France

[2] IRCCS, Assoc Oasi Maria SS, Inst Res Mental Retardat & Brain Aging, I-94018 Troina, EN, Italy

[3] CI Columbus, UCSC, Dept Internal Med & Geriatr, Rome, Italy

[4] Univ Catania, Dept Psychiat, Catania, Italy

来源：

NEUROREPORT | 2004年 / 15卷 / 05期

关键词：

Alzheimer's disease; homocysteine; methylene tetrahydrofolate reductase; transcobalamin;

D O I：

10.1097/00001756-200404090-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Homocysteine metabolism is influenced by genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR 677 C T and 1298 --> C) and transcobalamin genes (TCNI 776 C --> G). We evaluated the association of homocysteine with Alzheimer's disease (AD) and the influence of related polymorphisms and APOE, in 180 cases and 181 controls from southern Italy. Homocysteine (upper tercile) was associated with AD risk, with an odds ratio of 2.8 (95% confidence interval (Cl) 1.54-5.22, p=0.0008), which was increased 2.2- and 2.0-fold by MTHFR 677T (odds ratio 6.28, 95% Cl 2.88-16.20, p < 0.0001) and APOE is an element of 4 (odds ratio: 5.60, 95% Cl 1.12-28.05, p=0.0361), respectively In conclusion, association of homocysteine with AD was aggravated by MTHFR 677T and APOE is an element of 4 alleles.

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页码：859 / 861

页数：3

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