PRIMARY SCLEROSING CHOLANGITIS What is the role of ursodeoxycholic acid in therapy for PSC?

被引：8

作者：

Chapman, Roger W. ^{[1
]}

机构：

[1] John Radcliffe Hosp, Dept Gastroenterol & Hepatol, Oxford OX3 7RN, England

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2010年 / 7卷 / 02期

关键词：

MICE;

D O I：

10.1038/nrgastro.2009.235

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Ursodeoxycholic acid (UDCA) is widely used for the treatment of chronic cholestatic liver diseases. however, a recent randomized, controlled trial has surprisingly shown that the use of high-dose UDCA in patients with primary sclerosing cholangitis (PSC) may be harmful; adverse events, such as death and liver transplantation, were significantly higher in patients who received UDCA compared with placebo.

引用

页码：74 / 75

页数：3

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