Tumour biology and histopathology of neuroendocrine tumours

被引：124

作者：

Kloeppel, Guenter ^{[1
]}

机构：

[1] Univ Kiel, Dept Pathol, D-24105 Kiel, Germany

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2007年 / 21卷 / 01期

关键词：

neuroendocrine tumours; classification; typing; staging; prognosis;

D O I：

10.1016/j.beem.2007.01.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The tumours of the disseminated/diffuse neuroendocrine cell system are a group of neoplasms sharing uniformly appearing cells which differ from each other in their biology, prognosis and genetics. In the lung they are called carcinoid and small/large-cell neuroendocrine carcinomas. In the gastroenteropancreatic compartment they are classified as well-differentiated neuroendocrine tumours or carcinomas and poorly differentiated neuroendocrine carcinomas. Depending on their localization these neoplasms reveal distinct phenotypes with respect to pathology, immunohistochemistry, and hormonal syndromes. Their clinical behaviour - ranging from benign and low-grade to high-grade malignancy - can be predicted on the basis of clinicopathological criteria. Currently extensive work is being performed to unravel the genetic background.

引用

页码：15 / 31

页数：17

共 49 条

[1]

Asa SL, 1998, FUNCTIONAL ENDOCRINE, P415

[2] Deletion at 3p25.3-p23 is frequently encountered in endocrine pancreatic tumours and is associated with metastatic progression [J].