The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness

被引：309

作者：

Wang, Zhiwei ^{[1
]}

Li, Yiwei ^{[1
]}

Kong, Dejuan ^{[1
]}

Sarkar, Fazlul H. ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Karmanos Canc Inst, Dept Pathol, Detroit, MI 48201 USA

来源：

CURRENT DRUG TARGETS | 2010年 / 11卷 / 06期

关键词：

Notch; EMT; cancer; FACTOR-KAPPA-B; ACUTE LYMPHOBLASTIC-LEUKEMIA; GAMMA-SECRETASE INHIBITORS; CELL-GROWTH INHIBITION; DOWN-REGULATION; PDGF-D; SLUG EXPRESSION; BREAST-CANCER; CROSS-TALK; ACTIVATION;

D O I：

10.2174/138945010791170860

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The Notch signaling pathway maintains a balance between cell proliferation and apoptosis, and thus it is believed that Notch signaling pathway may play an important role in the development and progression of several malignancies. However, the functions of Notch signaling in EMT are largely unknown. This mini review describes the role of Notch signaling pathway in EMT, and cataloging how its deregulation is involved in EMT and tumor aggressiveness. Further attempts have been made to summarize the role of several chemopreventive agents that could be useful for targeted inactivation of Notch signaling, and thus it may cause reversal of EMT, which could become a novel approach for cancer prevention and treatment.

引用

页码：745 / 751

页数：7

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