Pitfalls in spontaneous in vitro transformation of human mesenchymal stem cells

被引:127
作者
Garcia, S. [2 ]
Bernad, A. [2 ,4 ]
Martin, M. C. [3 ]
Cigudosa, J. C. [3 ]
Garcia-Castro, J. [1 ,4 ]
de la Fuente, R. [4 ]
Bernad, A. [2 ,4 ]
Garcia-Castro, J. [1 ,4 ]
机构
[1] Inst Salud Carlos III, Area Biol Celular & Desarrollo, Madrid 28220, Spain
[2] Ctr Nacl Invest Cardiovasc Carlos III, Regenerat Cardiol Dept, Melchor Fernandez Almagro 3, Madrid 28029, Spain
[3] Ctr Nacl Invest Oncol, Cytogenet Unit, Madrid 28029, Spain
[4] UAM, Ctr Nacl Biotecnol, Dept Immunol & Oncol, Madrid 28049, Spain
关键词
D O I
10.1016/j.yexcr.2010.02.016
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1648 / 1650
页数:3
相关论文
共 12 条
[1]   Human bone marrow-derived mesenchymal stem cells do not undergo transformation after long-term In vitro culture and do not exhibit telomere maintenance mechanisms [J].
Bernardo, Maria Ester ;
Zaffaroni, Nadia ;
Novara, Francesca ;
Cometa, Angela Maria ;
Avanzini, Maria Antonietta ;
Moretta, Antonia ;
Montagna, Daniela ;
Maccario, Rita ;
Villa, Raffaella ;
Daidone, Maria Grazia ;
Zuffardi, Orsetta ;
Locatelli, Franco .
CANCER RESEARCH, 2007, 67 (19) :9142-9149
[2]   NORMAL KERATINIZATION IN A SPONTANEOUSLY IMMORTALIZED ANEUPLOID HUMAN KERATINOCYTE CELL-LINE [J].
BOUKAMP, P ;
PETRUSSEVSKA, RT ;
BREITKREUTZ, D ;
HORNUNG, J ;
MARKHAM, A ;
FUSENIG, NE .
JOURNAL OF CELL BIOLOGY, 1988, 106 (03) :761-771
[3]   Marrow-derived mesenchymal stem cells:: Role in epithelial tumor cell determination [J].
Fierro, FA ;
Sierralta, WD ;
Epuñan, MJ ;
Minguell, JJ .
CLINICAL & EXPERIMENTAL METASTASIS, 2004, 21 (04) :313-319
[4]   Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model [J].
Nakamura, K ;
Ito, Y ;
Kawano, Y ;
Kurozumi, K ;
Kobune, M ;
Tsuda, H ;
Bizen, A ;
Honmou, O ;
Niitsu, Y ;
Hamada, H .
GENE THERAPY, 2004, 11 (14) :1155-1164
[5]   Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells [J].
Otsu, Keishi ;
Das, Shonit ;
Houser, Sandra D. ;
Quadri, Sadiqa K. ;
Bhattacharya, Sunita ;
Bhattacharya, Jahar .
BLOOD, 2009, 113 (18) :4197-4205
[6]   Long-term Cultures of Bone Marrow-Derived Human Mesenchymal Stem Cells Frequently Undergo Spontaneous Malignant Transformation (This article contains errors due to a cross contamination of the cell lines we used. To correct this issue we published a letter in Cancer Res. 2010 Aug 1,70(15),6393-6) [J].
Rosland, Gro Vatne ;
Svendsen, Agnete ;
Torsvik, Anja ;
Sobala, Ewa ;
McCormack, Emmet ;
Immervoll, Heike ;
Mysliwietz, Josef ;
Tonn, Joerg-Christian ;
Goldbrunner, Roland ;
Lonning, Per Eystein ;
Bjerkvig, Rolf ;
Schichor, Christian .
CANCER RESEARCH, 2009, 69 (13) :5331-5339
[7]   RETRACTED: Spontaneous human adult stem cell transformation (Retracted article. See vol. 70, pg. 6682, 2010) [J].
Rubio, D ;
Garcia-Castro, J ;
Martín, MC ;
de la Fuente, R ;
Cigudosa, JC ;
Lloyd, AC ;
Bernad, A .
CANCER RESEARCH, 2005, 65 (08) :3035-3039
[8]   Human mesenchymal stem cell transformation is associated with a mesenchymal-epithelial transition [J].
Rubio, Daniel ;
Garcia, Silvia ;
De la Cueva, Teresa ;
Paz, M. F. ;
Lloyd, Alison C. ;
Bernad, Antonio ;
Garcia-Castro, Javier .
EXPERIMENTAL CELL RESEARCH, 2008, 314 (04) :691-698
[9]   Molecular Characterization of Spontaneous Mesenchymal Stem Cell Transformation [J].
Rubio, Daniel ;
Garcia, Silvia ;
Paz, Maria F. ;
De la Cueva, Teresa ;
Lopez-Fernandez, Luis A. ;
Lloyd, Alison C. ;
Garcia-Castro, Javier ;
Bernad, Antonio .
PLOS ONE, 2008, 3 (01)
[10]   Adult human mesenchymal stem cell as a target for neoplastic transformation [J].
Serakinci, N ;
Guldberg, P ;
Burns, JS ;
Abdallah, B ;
Schrodder, H ;
Jensen, T ;
Kassem, M .
ONCOGENE, 2004, 23 (29) :5095-5098