Cancer stem cells: small subpopulation or evolving fraction?

被引：41

作者：

Enderling, Heiko ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Integrated Math Oncol, Tampa, FL 33612 USA

来源：

INTEGRATIVE BIOLOGY | 2015年 / 7卷 / 01期

关键词：

TUMOR-INITIATING CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; SELF-RENEWAL; MATHEMATICAL-MODELS; PROSPECTIVE IDENTIFICATION; MYELOID-LEUKEMIA; DRUG-RESISTANCE; PROSTATE-CANCER; SOLID TUMORS;

D O I：

10.1039/c4ib00191e

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel, integrated interdisciplinary studies is offered.

引用

页码：14 / 23

页数：10

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