Estimates of the infectious reservoir of Plasmodium falciparum malaria in The Gambia and in Tanzania

被引:82
作者
Drakeley, CJ
Akim, NIJ
Sauerwein, RW
Greenwood, BM
Targett, GAT
机构
[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England
[2] MRC Labs, Fajara, Gambia
[3] Ifakara Hlth Res & Dev Ctr, Ifakara, Tanzania
[4] Univ Nijmegen, Univ Nijmegen Hosp, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands
基金
英国医学研究理事会;
关键词
malaria; Plasmodium falciparum; infectious reservoir; The Gambia; Tanzania;
D O I
10.1016/S0035-9203(00)90056-7
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Separate studies carried out in Farafenni, The Gambia and Ifakara, Tanzania in 1990-94 provided comparative data on population age structure, population gametocyte prevalences and gametocyte carrier infectivity. The percentage of the population estimated to be infective to mosquitoes was 5(.)5% and 3(.)8% in The Gambia and Tanzania, respectively. The age groups 1-4 years, 5-9 years, 10-19 years and 20 years or more comprised 17(.)5%, 21(.)7%, 22(.)2% and 37(.)9%, respectively, of the infectious population in The Gambia; the corresponding figures for Tanzania were 30(.)9%, 25(.)2%, 15(.)7% and 28(.)1%. These figures are in broad agreement with those from other published studies which estimated the infectious reservoir directly and suggest that adults contribute significantly to the infectious reservoir of malaria, particularly in areas of intense seasonal transmission. Control measures aimed at reduction of transmission may have only a limited effect in areas of moderate seasonal transmission if directed only at children.
引用
收藏
页码:472 / 476
页数:5
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