Sarcomas

被引：53

作者：

HaDuong, Josephine H. ^{[1
]}

Martin, Andrew A. ^{[2
]}

Skapek, Stephen X. ^{[2
]}

Mascarenhas, Leo ^{[1
]}

机构：

[1] Univ So Calif, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Dept Pediat,Childrens Ctr Canc & Blood Dis,Keck S, Los Angeles, CA 90027 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pediat, Pauline Allen Gill Ctr Canc & Blood Disorders, Div Hematol Oncol,Childrens Med Ctr, Dallas, TX 75390 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2015年 / 62卷 / 01期

关键词：

Soft-tissue sarcoma; Rhabdomyosarcoma; Nonrhabdomyosarcoma; Bone; Ewing's; Osteosarcoma; PRIMITIVE NEUROECTODERMAL TUMOR; NONMETASTATIC EWINGS-SARCOMA; HIGH-GRADE OSTEOSARCOMA; SOFT-TISSUE SARCOMAS; PROGNOSTIC-FACTORS; NEOADJUVANT CHEMOTHERAPY; ALVEOLAR RHABDOMYOSARCOMA; SINGLE INSTITUTION; MOLECULAR-BIOLOGY; FAMILY TUMORS;

D O I：

10.1016/j.pcl.2014.09.012

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Malignant bone tumors (osteosarcoma, Ewing sarcoma) and soft-tissue sarcomas (rhabdomyosarcoma, nonrhabdomyosarcoma) account for approximately 14% of childhood malignancies. Successful treatment of patients with sarcoma depends on a multidisciplinary approach to therapy, including oncology, surgery, radiation oncology, radiology, pathology, and physiatry. By combining systemic treatment with chemotherapy and primary tumor control using surgery and/or radiation, survival rates for localized disease range from 70% to 75%. However, children with metastatic or recurrent disease continue to have dismal outcomes. A better understanding of the biology underlying both bone and soft-tissue sarcomas is required to further improve outcomes for children with these tumors.

引用

页码：179 / +

页数：23

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