共 29 条
Structure of the human Nkx2.1 gene
被引:56
作者:

Hamdan, H
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Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA

Liu, HB
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Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA

Li, CG
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Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA

Jones, C
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Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA

Lee, M
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Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA

deLemos, R
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Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA

Minoo, P
论文数: 0 引用数: 0
h-index: 0
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Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA
机构:
[1] Univ So Calif, Sch Med, Womens & Childrens Hosp, Dept Pediat, Los Angeles, CA 90033 USA
来源:
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
|
1998年
/
1396卷
/
03期
关键词:
Nkx2.1;
lung development;
homeoprotein;
genomic clone;
promoter domain;
D O I:
10.1016/S0167-4781(97)00210-8
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
NKX2.1 is a member of the NK2 family of homeodomain-containing transcriptional factors which binds to and activates the promoters of thyroid and pulmonary epithelial genes. We have cloned and sequenced twelve human lung Nkx2.1 cDNAs. To elucidate the origin of Nkr2.1 transcripts, we also cloned and sequenced a 12 kb human Nkx2.1 genomic clone. Alignment of cDNA sequences with the genomic clone showed that contrary to previous reports, the human Nkx2.1 gene is organized into three exons and two introns. The newly discovered exon I contains an ATG codon that falls in frame with the previously identified Nkx2.1 initiator ATG codon on one of the cDNAs, designated 5E. Northern blot analysis shows that an mRNA of approximately 2.5 kb in size, homologous to 5E, is expressed in both lung and thyroid, The deduced amino acid sequence of the longest open reading frame on 5E is identical to NKX2.1 with the exception of a 30 amino acid N-terminal extension. Coupled in vitro transcription/translation of the 5E cDNA confirms that the open reading frame is translated into a contiguous polypeptide of 44 kDa. Analysis of Nkx2.1 genomic DNA fragments suggest that at least two independent regions, one within the first intron and the other 5' of the first exon may mediate the basal promoter activity of the Nkx2.1 gene in lung epithelial cells. (C) 1998 Elsevier Science B.V.
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页码:336 / 348
页数:13
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- [1] THE DNA-BINDING ACTIVITY AND THE DIMERIZATION ABILITY OF THE THYROID TRANSCRIPTION FACTOR-I ARE REDOX REGULATED[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (20) : 12048 - 12055ARNONE, MI论文数: 0 引用数: 0 h-index: 0机构: Staz Zool Anton Dohrn, I-81021 NAPLES, ITALY Staz Zool Anton Dohrn, I-81021 NAPLES, ITALYZANNINI, M论文数: 0 引用数: 0 h-index: 0机构: Staz Zool Anton Dohrn, I-81021 NAPLES, ITALY Staz Zool Anton Dohrn, I-81021 NAPLES, ITALYDILAURO, R论文数: 0 引用数: 0 h-index: 0机构: Staz Zool Anton Dohrn, I-81021 NAPLES, ITALY Staz Zool Anton Dohrn, I-81021 NAPLES, ITALY
- [2] THE LUNG-SPECIFIC SURFACTANT PROTEIN-B GENE PROMOTER IS A TARGET FOR THYROID TRANSCRIPTION FACTOR-1 AND HEPATOCYTE NUCLEAR FACTOR-3, INDICATING COMMON FACTORS FOR ORGAN-SPECIFIC GENE-EXPRESSION ALONG THE FOREGUT AXIS[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (09) : 5671 - 5681BOHINSKI, RJ论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP, MED CTR, DIV PULM BIOL, CINCINNATI, OH 45229 USADILAURO, R论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP, MED CTR, DIV PULM BIOL, CINCINNATI, OH 45229 USAWHITSETT, JA论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP, MED CTR, DIV PULM BIOL, CINCINNATI, OH 45229 USA
- [3] LUNG CELL-SPECIFIC EXPRESSION OF THE MURINE SURFACTANT PROTEIN-A (SP-A) GENE IS MEDIATED BY INTERACTIONS BETWEEN THE SP-A PROMOTER AND THYROID TRANSCRIPTION FACTOR-I[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (12) : 6531 - 6536BRUNO, MD论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,CINCINNATI,OH 45229 CHILDRENS HOSP,MED CTR,DIV PULM BIOL,CINCINNATI,OH 45229BOHINSKI, RJ论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,CINCINNATI,OH 45229 CHILDRENS HOSP,MED CTR,DIV PULM BIOL,CINCINNATI,OH 45229HUELSMAN, KM论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,CINCINNATI,OH 45229 CHILDRENS HOSP,MED CTR,DIV PULM BIOL,CINCINNATI,OH 45229WHITSETT, JA论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,CINCINNATI,OH 45229 CHILDRENS HOSP,MED CTR,DIV PULM BIOL,CINCINNATI,OH 45229KORFHAGEN, TR论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,CINCINNATI,OH 45229 CHILDRENS HOSP,MED CTR,DIV PULM BIOL,CINCINNATI,OH 45229
- [4] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE[J]. BIOCHEMISTRY, 1979, 18 (24) : 5294 - 5299CHIRGWIN, JM论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143 UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143PRZYBYLA, AE论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143 UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143MACDONALD, RJ论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143 UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143RUTTER, WJ论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143 UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
- [5] A THYROID-SPECIFIC NUCLEAR-PROTEIN ESSENTIAL FOR TISSUE-SPECIFIC EXPRESSION OF THE THYROGLOBULIN PROMOTER[J]. EMBO JOURNAL, 1989, 8 (09) : 2537 - 2542CIVITAREALE, D论文数: 0 引用数: 0 h-index: 0LONIGRO, R论文数: 0 引用数: 0 h-index: 0SINCLAIR, AJ论文数: 0 引用数: 0 h-index: 0DILAURO, R论文数: 0 引用数: 0 h-index: 0
- [6] SEQUENCE-SPECIFIC DNA RECOGNITION BY THE THYROID TRANSCRIPTION FACTOR-I HOMEODOMAIN[J]. NUCLEIC ACIDS RESEARCH, 1994, 22 (15) : 3075 - 3083DAMANTE, G论文数: 0 引用数: 0 h-index: 0机构: EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANYFABBRO, D论文数: 0 引用数: 0 h-index: 0机构: EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANYPELLIZZARI, L论文数: 0 引用数: 0 h-index: 0机构: EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANYCIVITAREALE, D论文数: 0 引用数: 0 h-index: 0机构: EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANYGUAZZI, S论文数: 0 引用数: 0 h-index: 0机构: EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANYPOLYCARPOUSCHWARTZ, M论文数: 0 引用数: 0 h-index: 0机构: EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANYCAUCI, S论文数: 0 引用数: 0 h-index: 0机构: EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANYQUADRIFOGLIO, F论文数: 0 引用数: 0 h-index: 0机构: EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANYFORMISANO, S论文数: 0 引用数: 0 h-index: 0机构: EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANYDILAURO, R论文数: 0 引用数: 0 h-index: 0机构: EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY
- [7] STRUCTURE OF THE RAT-THYROID TRANSCRIPTION FACTOR-I (TTF-1) GENE[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 204 (03) : 1358 - 1363ENDO, T论文数: 0 引用数: 0 h-index: 0机构: Univ Yamanashi, Sch Med, Dept Internal Med 3, Yamanashi, 40938, TamahoOHTA, K论文数: 0 引用数: 0 h-index: 0机构: Univ Yamanashi, Sch Med, Dept Internal Med 3, Yamanashi, 40938, TamahoSAITO, T论文数: 0 引用数: 0 h-index: 0机构: Univ Yamanashi, Sch Med, Dept Internal Med 3, Yamanashi, 40938, TamahoHARAGUCHI, K论文数: 0 引用数: 0 h-index: 0机构: Univ Yamanashi, Sch Med, Dept Internal Med 3, Yamanashi, 40938, TamahoNAKAZATO, M论文数: 0 引用数: 0 h-index: 0机构: Univ Yamanashi, Sch Med, Dept Internal Med 3, Yamanashi, 40938, TamahoKOGAI, T论文数: 0 引用数: 0 h-index: 0机构: Univ Yamanashi, Sch Med, Dept Internal Med 3, Yamanashi, 40938, TamahoONAYA, T论文数: 0 引用数: 0 h-index: 0机构: Univ Yamanashi, Sch Med, Dept Internal Med 3, Yamanashi, 40938, Tamaho
- [8] THE THYROID TRANSCRIPTION FACTOR-I GENE IS A CANDIDATE TARGET FOR REGULATION BY HOX PROTEINS[J]. EMBO JOURNAL, 1994, 13 (14) : 3339 - 3347GUAZZI, S论文数: 0 引用数: 0 h-index: 0机构: UNIV UDINE, DEPT SCI & BIOMED TECHNOL, I-33100 UDINE, ITALYLONIGRO, R论文数: 0 引用数: 0 h-index: 0机构: UNIV UDINE, DEPT SCI & BIOMED TECHNOL, I-33100 UDINE, ITALYPINTONELLO, L论文数: 0 引用数: 0 h-index: 0机构: UNIV UDINE, DEPT SCI & BIOMED TECHNOL, I-33100 UDINE, ITALYBONCINELLI, E论文数: 0 引用数: 0 h-index: 0机构: UNIV UDINE, DEPT SCI & BIOMED TECHNOL, I-33100 UDINE, ITALYDILAURO, R论文数: 0 引用数: 0 h-index: 0机构: UNIV UDINE, DEPT SCI & BIOMED TECHNOL, I-33100 UDINE, ITALYMAVILIO, F论文数: 0 引用数: 0 h-index: 0机构: UNIV UDINE, DEPT SCI & BIOMED TECHNOL, I-33100 UDINE, ITALY
- [9] THYROID NUCLEAR FACTOR-I (TTF-1) CONTAINS A HOMEODOMAIN AND DISPLAYS A NOVEL DNA-BINDING SPECIFICITY[J]. EMBO JOURNAL, 1990, 9 (11) : 3631 - 3639GUAZZI, S论文数: 0 引用数: 0 h-index: 0机构: HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCE HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCEPRICE, M论文数: 0 引用数: 0 h-index: 0机构: HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCE HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCEDEFELICE, M论文数: 0 引用数: 0 h-index: 0机构: HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCE HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCEDAMANTE, G论文数: 0 引用数: 0 h-index: 0机构: HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCE HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCEMATTEI, MG论文数: 0 引用数: 0 h-index: 0机构: HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCE HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCEDILAURO, R论文数: 0 引用数: 0 h-index: 0机构: HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCE HOP ENFANTS LA TIMONE, INSERM, UNITE PHYSIOPATHOL CHROMOSOM 242, F-13385 MARSEILLE 5, FRANCE
- [10] GENE STRUCTURE AND EXPRESSION OF HUMAN THYROID TRANSCRIPTION FACTOR-I IN RESPIRATORY EPITHELIAL-CELLS[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (14) : 8108 - 8114IKEDA, K论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,TCHRF,CINCINNATI,OH 45229CLARK, JC论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,TCHRF,CINCINNATI,OH 45229SHAWWHITE, JR论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,TCHRF,CINCINNATI,OH 45229STAHLMAN, MT论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,TCHRF,CINCINNATI,OH 45229BOUTELL, CJ论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,TCHRF,CINCINNATI,OH 45229WHITSETT, JA论文数: 0 引用数: 0 h-index: 0机构: CHILDRENS HOSP,MED CTR,DIV PULM BIOL,TCHRF,CINCINNATI,OH 45229