Highly enantioselective ene-type spiro-cyclization of allyl propargyl ethers catalyzed by cationic palladium(II) complexes with a new type of PN-ligand bearing achiral gem-dimethyl oxazoline

被引：21

作者：

Hatano, M ^{[1
]}

Mikami, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Grad Sch Sci & Engn, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2003年 / 196卷 / 1-2期

关键词：

asymmetric catalysis; cyclizations; enynes; PN-ligands; palladium; spiro;

D O I：

10.1016/S1381-1169(02)00647-7

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The first examples of the asymmetric ene-type spiro-cyclization catalyzed by cationic palladium(H) complexes with a new PN-ligand bearing achiral gem-dimethyl oxazoline unit were demonstrated. Spiro-products were synthesized from ether substrates with common, medium and large membered rings with high enantiomeric excesses in almost quantitative yields. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：165 / 169

页数：5

共 34 条

[1] Catalytic asymmetric synthesis of quaternary carbon centers.: Exploratory investigations of intramolecular Heck reactions of (E)-α,β-Unsaturated 2-haloanilides and analogues to form enantioenriched spirocyclic products [J].