p38 mitogen-activated protein kinases on the body surface -: A function for p38δ

被引：84

作者：

Eckert, RL

Efimova, T

Balasubramanian, S

Crish, JF

Bone, F

Dashti, S

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Phys & Biophys, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Sch Med, Dept Reprod Biol, Cleveland, OH 44106 USA

[4] Case Western Reserve Univ, Sch Med, Dept Oncol, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Sch Med, Dept Dermatol, Cleveland, OH 44106 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2003年 / 120卷 / 05期

关键词：

apoptosis; ERK; involucrin; keratinocyte differentiation; MAPK; p38; delta; gamma; signal transduction;

D O I：

10.1046/j.1523-1747.2003.12120.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The p38 family of mitogen-activated protein kinases includes p38alpha (SAPK2a, CSBP), p38beta (SAPK2b), p38delta (SAPK4), and p38gamma (SAPK3/ERK6). p38alpha and p38beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. Relatively less is known regarding the function of the p38delta isoform. In this review, we discuss the role of the p38alpha, p38beta, and p38gamma isoforms and then present recent findings that define a role for p38delta as a regulator of differentiation-dependent gene expression in keratinocytes.

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收藏

页码：823 / 828

页数：6

相关论文

共 100 条

[1] Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development [J].

Adams, RH ;

Porras, A ;

Alonso, G ;

Jones, M ;

Vintersten, K ;

Panelli, S ;

Valladares, A ;

Perez, L ;

Klein, R ;

Nebreda, AR .

MOLECULAR CELL, 2000, 6 (01) :109-116

[2] CCAAT/enhancer-binding proteins - A role in regulation of human involucrin promoter response to phorbol ester [J].

Agarwal, C ;

Efimova, T ;

Welter, JF ;

Crish, JF ;

Eckert, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (10) :6190-6194

[3] Function and regulation of AP-1 subunits in skin physiology and pathology [J].

Angel, P ;

Szabowski, A ;

Schorpp-Kistner, M .

ONCOGENE, 2001, 20 (19) :2413-2423

[4] The role of p38 in UVA-induced cyclooxygenase-2 expression in the human keratinocyte cell line, HaCaT [J].

Bachelor, MA ;

Silvers, AL ;

Bowden, GT .

ONCOGENE, 2002, 21 (46) :7092-7099

[5] Thapsigargin suppresses phorbol ester-dependent human involucrin promoter activity by suppressing CCAAT-enhancer-binding protein α (C/EBPα) DNA binding [J].

Balasubramanian, S ;

Agarwal, C ;

Efimova, T ;

Dubyak, GR ;

Banks, E ;

Welter, J ;

Eckert, RL .

BIOCHEMICAL JOURNAL, 2000, 350 :791-796

[6] Green tea Polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes [J].

Balasubramanian, S ;

Efimova, T ;

Eckert, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (03) :1828-1836

[7] Transcription factor Sp1 activates involucrin promoter activity in non-epithelial cell types [J].

Banks, EB ;

Crish, JF ;

Eckert, RL .

BIOCHEMICAL JOURNAL, 1999, 337 :507-512

[8] Characterization of human involucrin promoter distal regulatory region transcriptional activator elements - a role for Sp1 and AP1 binding sites [J].

Banks, EB ;

Crish, JF ;

Welter, JF ;

Eckert, RL .

BIOCHEMICAL JOURNAL, 1998, 331 :61-68

[9] Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart - p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion [J].

Bogoyevitch, MA ;

GillespieBrown, J ;

Ketterman, AJ ;

Fuller, SJ ;

BenLevy, R ;

Ashworth, A ;

Marshall, CJ ;

Sugden, PH .

CIRCULATION RESEARCH, 1996, 79 (02) :162-173

[10] NORMAL KERATINIZATION IN A SPONTANEOUSLY IMMORTALIZED ANEUPLOID HUMAN KERATINOCYTE CELL-LINE [J].

BOUKAMP, P ;

PETRUSSEVSKA, RT ;

BREITKREUTZ, D ;

HORNUNG, J ;

MARKHAM, A ;

FUSENIG, NE .

JOURNAL OF CELL BIOLOGY, 1988, 106 (03) :761-771

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