An exploration of the periodontitis-cancer association

被引:211
作者
Hujoel, PP
Drangsholt, M
Spiekerman, C
Weiss, NS
机构
[1] Univ Washington, Sch Dent, Dept Dent Publ Hlth Sci, Seattle, WA 98195 USA
[2] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA
关键词
periodontitis; neoplasm of lung and bronchus; smoking; NHANES I;
D O I
10.1016/S1047-2797(02)00425-8
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
PURPOSE: Periodontitis has been linked to the occurrence of various systemic diseases. The goal of this study was to explore the periodontitis-cancer association in the NHANES I Epidemiologic Follow-up Study. METHODS: Data were available on 11,328 adults, age 25 to 74 years, who were diagnosed as dentate individuals with either periodontitis (n = 2092), gingivitis (n = 2603), a healthy periodontium. (n = 2,671), or as individuals without teeth (edentulous n = 3,962) at the beginning of the follow-up. The main outcome measure was fatal cancer, as ascertained from death certificates. RESULTS: Compared with individuals with a healthy periodontium, fatal cancer occurrence was positively associated with periodontitis at baseline (age and gender adjusted odds ratio = 1.55, 95% confidence interval: 1.25-1.92). Of the different cancer types, lung cancer demonstrated the strongest association. After adjustment for known risk factors for lung cancer, the magnitude of the association between periodontitis and lung cancer ranged between 1.48 (95% confidence interval: 0.88-2.50) and 1.73 (95% confidence interval: 1.01-2.97). CONCLUSIONS: Associations between periodontitis and lung cancer mortality can be identified above and beyond adjustment for known risk factors for lung cancer. Despite these apparent unconfounded associations, there are reasons to believe that the periodontitis-cancer associations may be spurious. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:312 / 316
页数:5
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